Peter W. Laird on Muck Rack

Peter W. Laird

  • Research Scientist, DNA Methylation & Cancer Epigenetics Expert, Freelance
Grand Rapids
As seen in: Nature, ACS Publications, Flipboard, Cell Press, Genetic Engineering & Biotechnology News, Epigenomics, Future Medicine, Graphic Policy, Forces of Geek
DNA methylation & cancer epigenetics. Tweets are my own. I tend to stick to science.
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Articles

Three-dimensional genome landscape of primary human cancers - Nature Genetics

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By Kathryn E Yost, L. T. Hung, Kaiyuan Zhu, M. Ryan Corces, Shahab Sarmashghi, Laksshman Sundaram, Stanley Clarke, Ashley S. Doane, Hani Choudhry, Marcin Imielinski, Andrew D. Cherniack, Ekta Khurana, Vineet Bafna, Peter W. Laird, Christina Curtis, William J. Greenleaf
| Nature
Abstract Genome conformation underlies transcriptional regulation by distal enhancers, and genomic rearrangements in cancer can alter critical regulatory interactions. Here we profiled the three-dimensional genome architecture and enhancer connectome of 69 tumor samples spanning 15 primary human cancer types from The Cancer Genome Atlas. We discovered the following three archetypes of enhancer usage for over 100 oncogenes across human cancers: static, selective gain or dynamic rewiring.
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Ultrasensitive Amplification-Free Quantification of a Methyl CpG-Rich Cancer Biomarker by Single-Molecule Kinetic Fingerprinting

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By Liuhan Dai, Alexander Johnson-Buck, Peter W. Laird, Muneesh Tewari
| ACS Publications
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Ultrasensitive Amplification-Free Quantification of a Methyl CpG-Rich Cancer Biomarker by Single-Molecule Kinetic Fingerprinting

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By Liuhan Dai, Alexander Johnson-Buck, Peter W. Laird, Muneesh Tewari
| dx.doi.org
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