Petr Baranov

Keywords regeneration systemic responses peripheral nervous system norepinephrine noradrenaline mTOR stem cells progenitor cells limb amputation Introduction The ability to spontaneously replace large body parts lost to injury or disease varies across the animal kingdom. Salamanders, such as axolotls, can regenerate full limbs, but mammals cannot. Relatively little is known about how selective pressures experienced by salamanders might have shaped their remarkable regenerative traits.

Abstract Tissue development is a complex spatiotemporal process with multiple interdependent components. Anatomical, histological, sequencing, and evolutional strategies can be used to profile and explain tissue development from different perspectives. The introduction of scRNAseq methods and the computational tools allows to deconvolute developmental heterogeneity and draw a decomposed uniform map.