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Jason D. Buenrostro on Muck Rack

Jason D. Buenrostro

Cambridge
As seen in: Nature, Genome Biology, BioRxiv, Cell Press, Cell Stem Cell, EIN News, Broad Institute, Annual Reviews Journal, EIN Presswire, Medical Industry Today and
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Articles

Biological aging and generational shifts in early-onset cancer risk

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By Ruiyi Tian, Xiaoyu Zong, Duo Ren, Stefani Tica, Daniel Hong, Oluseye K. Oduyale, Jason D. Buenrostro, Ramaswamy Govindan, Yin Cao
| Nature Verified
Abstract Incidence of early-onset cancer is rising globally in recent generations, which underscores the need to elucidate the influence of emerging generational risk factors. Systemic and organ-specific aging reflects the cumulative impact of exposures and may provide an integrative and complementary approach to understand early-onset cancer risk.
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Epigenetic memory of colitis promotes tumour growth

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By Surya Nagaraja, Lety Ojeda-Miron, Ruochi Zhang, Ena Oreskovic, Conrad Hock, Yan Hu, Daniel Zeve, Karina Sharma, Roni R. Hyman, Qiming Zhang, David Breault, Omer Yilmaz, Ömer H. Yilmaz, Jason D. Buenrostro
| Nature Verified
Abstract Chronic inflammation is a well-established risk factor for cancer, but the underlying molecular mechanisms remain unclear1,2. Using a mouse model of colitis, we demonstrate that colonic stem cells retain an epigenetic memory of inflammation following disease resolution that persists for more than 100 days. Here we find that memory of colitis is characterized by a cumulative gain of activator protein 1 (AP-1) transcription factor activity, with durable changes to chromatin accessibility.
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Biology of Adversity Project launches at Broad Institute

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By Jason D. Buenrostro
| EIN Presswire
Most people have experienced distressing events in their lives, such as violence, neglect, or natural disasters. These and other kinds of adverse experiences can have dramatic effects on physical and mental health, yet scientists don't fully understand how they affect the body at the cellular and molecular level.
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