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Articles by Philipp Lang
Glutathione is critical for NK cell-mediated immunity
Keywords NK cells glutathione IL-15 cancer LCMV mTOR immunometabolism metastasis redox metabolism cytotoxic T cells Research topic(s) CP: immunology CP: metabolism Introduction Reactive oxygen species (ROS) are generated by various mechanisms, with mitochondria being a major source.1,2,3 Excessive accumulation of ROS alters protein structure, impairing cellular function.
Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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Keywords LCMV virotherapy tumor-tropic arenavirus anti-tumor immunity cancer-selective viral replication attenuated virus immune activation anti-tumoral T cell engager Introduction Cancer cells show strongly enhanced anabolism, making them ideal hosts for viral replication.1 Furthermore, cancer cells lack cell autonomous immunity, since cellular antiviral mechanisms are actively suppressed by oncogenes.1 For example, overexpression of rat sarcoma (RAS) oncogenes can block the activity of the...
By Philipp Lang, Lisa Holnsteiner, Yara M Machlah, Sarah-Kim Friedrich-Becker, Michael Bergerhausen, Rosa Schmitz, Maximilian Schiller, Tim Brandenburg, Julia Zöller, Julia Werner, Marla Keizers, Michal Gorzkiewicz, Arshia Berry, Lara Jelic, Piyush Pandey, Ruifeng Wang, Dethardt Müller, Marcus Kostka, Cornelia Hardt, Jörg Vollmer, Haifeng Xu, Karl S. Lang
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Cell Reports Medicine
Verified
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity
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Keywords immunometabolism viral infection inner mitochondrial membrane MIC60 MICOS mitochondria innate immunity BMDC itaconate Research topic(s) CP: Microbiology CP: Cell biology Introduction Viral infections remain a global health problem with countless infections worldwide and potential risks for outbreaks causing enormous harm to humans and society. Viruses hijack the host cells to propagate and are therefore known to influence cellular processes.
By Ichiro Katahira, Nina A. Liebrand, Michal Gorzkiewicz, Niklas Paul Klahm, Julia Werner, Karina Stephanie Krings, Sarah Orywol, Tobias Lautwein, Karl Köhrer, Diran Herebian, Ertan Mayatepek, Max Anstötz, Ann Kathrin Bergmann, Arun Kumar Kondadi, Haifeng Xu, Aleksandra A. Pandyra, Takumi Kobayashi, Dirk Brenner, Thomas Flöss, Ulrich Kalinke, Andreas Reichert, Philipp Lang
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Cell Reports
Verified
In aller Freundschaft - Die jungen Ärzte
Gleich zu Beginn des Tages bekommt Assistenzarzt Olli Probst ordentlich Druck. Er ist der Einzige, der noch nicht seinen ersten Hautschnitt machen durfte. Er fühlt sich in die Ecke gedrängt. Da kommt es Olli gelegen, dass er mit Dr. Julia Berger eingeteilt ist und die schwangere Silvana Reski aufnehmen darf. Dr. Leyla Sherbaz und Assistenzarzt Ivo Maric nehmen indes Klaus Maier auf, der mit einem Messer im Bauch ins JKT kommt und sofort operiert werden muss.
Abzug der Bundeswehr aus Mali: Die humanitäre Hilfe in der Sahelzone braucht einen Neustart
Die Krise im westafrikanischen Mali verschärft sich. In weiten Teilen des Landes haben terroristisch-dschihadistische Gruppen die Kontrolle übernommen. Hundertausende wurden aus ihren Dörfern vertrieben, Millionen sind auf Unterstützung angewiesen. Immer wieder kommt es zu brutalen Angriffen auf die Zivilbevölkerung. Die Tagesspiegel-App Aktuelle Nachrichten, Hintergründe und Analysen direkt auf Ihr Smartphone. Dazu die digitale Zeitung. Hier gratis herunterladen.
Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection
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Waldmark Horn feiert 119. Stiftungsfest
Vom 12. bis zum 13. Mai 2023 feierte die katholische Mittelschulverbindung Waldmark Horn ihr Stiftungsfest anlässlich ihres 119-jährigen Bestehens. Die Feierlichkeiten starteten am Freitagabend mit einer Weinverkostung im Vereinslokal, der Bude. Johannes Hofbauer Schmidt (Weingut Hofbauer-Schmidt, Hohenwarth) und Klaus Schmuckenschlager (Weingut Schmuckenschlager, Klosterneuburg) präsentierten eine Auswahl ihrer Weine und luden die Anwesenden zum Probieren ein.
Unexpected wavelength dependency of the photocatalytic CO2 reduction performance of the well-known (bpy)Re(CO)3Cl complex
Unexpected wavelength dependency of the photocatalytic CO2 reduction performance of the well-known (bpy)Re(CO)3Cl complex The selective photocatalytic reduction of CO2 to CO has often been accomplished using complexes incorporating the Re(CO)3Cl fragment.
Unexpected wavelength dependency of the photocatalytic CO2 reduction performance of the well-known (bpy)Re(CO)3Cl
P. Lang, R. Giereth, S. Tschierlei and M. Schwalbe, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC08742C If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center. Go to our Instructions for using Copyright Clearance Center page for details.
Disentangling entanglements in biopolymer solutions
To learn how the polymers first entangle and then disentangle, i.e., how topological constraints emerge and are released, we studied the dynamics of individual (tracer) polymers in an entangled polymer solution; see Supplementary Movie 1.
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