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Articles by Pingping Han
Salivary Microvesicle Methylome and Microbiome Profiles in Periodontitis: An Exploratory Study
1 Introduction Periodontitis, a chronic inflammatory oral disease, is caused by a microbial dysbiosis associated destructive host immune response, where the interplay between dental plaque, genetics and epigenetics leads to irreversible loss of tooth-supporting tissues (Hajishengallis and Chavakis 2021; Lamont et al. 2018; Loos and Van Dyke 2020). Current clinical diagnosis relies on detecting past tissue damage (i.e., probing pocket depth [PPD], clinical attachment loss [CAL]) (Salvi et al.
Extracellular Vesicles in Gingival Crevicular Fluid as Indicators of Periodontitis and Early Response to Non‐surgical Periodontal Therapy
Disclosure AI statement: This manuscript did not use artificial intelligence in any capacity. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Association Between Salivary Circular RNAs Expression and Periodontal Disease Status
1 Introduction Periodontitis is a chronic inflammatory disease driven by immune dysregulation and oral biofilm dysbiosis, leading to periodontal tissue destruction. Alongside genetics, epigenetic factors like bacteria, stress and lifestyle contribute to periodontitis. Traditional clinical diagnostics reflect past activity but not current disease status [1], highlighting the need for new saliva-based epigenetic biomarkers for improved disease detection.
Effects of a ‘Rebuilding Myself’ intervention on enhancing the adaptability of cancer patients to return to work: a randomized controlled trial - BMC Cancer
This research was carried out between January 2022 and December 2022. A single-blind, randomized, controlled trial was conducted at a single center with two parallel groups, and the paper was prepared in accordance with the Consolidated Standards for Reporting Trials (CONSORT 2010) [24].
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
Acute ischemic stroke is a leading cause of morbidity and mortality worldwide, producing devastating and permanent neurological damage.1,2 Perturbation of cerebral blood flow (CBF) during ischemic stroke limits the delivery of oxygen and energy substrate, leading to the dysfunction of mitochondrial oxidative phosphorylation and cellular bioenergetic stress.3 The burden of ischemic stroke continues to rise due to the increased prevalence of risk factors, including hypertension, obesity and...
Single-Cell RNA-Sequencing Reveals Heterogeneity and Transcriptional Dynamics in Porcine Circulating CD8+ T Cells
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Evaluating models and assessment techniques for understanding oral biofilm complexity
1 INTRODUCTION Periodontitis and caries are common biofilm-mediated dental diseases, which if untreated, may lead to loss of teeth (Chen et al., 2021; Wen et al., 2022). Even though the prevalence of caries is decreasing in the developed world, it remains high in developing and underdeveloped countries, making caries a global health challenge (Wen et al., 2022).
Effects of periodontal cells‐derived extracellular vesicles on mesenchymal stromal cell function
1 INTRODUCTION Bone regeneration is an important biological process that involves stimulating mesenchymal stem/stromal cells (MSCs) committed to osteogenesis, and a primary goal of bioengineered MSCs is to restore the structure and function of bones after experiencing an injury, trauma or disease1, 2 Various methods, including guided bone regeneration, bone grafting, cell therapy and the use of growth factors or other biological molecules (i.e. extracellular vesicles3-5), can be employed to...
How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk
1 Introduction While the term ‘diabetes’ is defined as an individual’s inability to regulate blood glucose concentrations with resultant chronic hyperglycemia, traditionally two major clinically distinct subtypes have been characterized. Type 1 diabetes (T1D) results from the complete autoimmune mediated destruction of the insulin producing beta (β) cells within the pancreatic islets (1).
The Mechanosensing and Global DNA Methylation of Human Osteoblasts on MEW Fibers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
Saliva tests could offer a better alternative to nasal COVID-19 swabs
Credit: Shutterstock Saliva is one of our biggest foes in the COVID-19 pandemic, because of its role in spreading the virus. But it could be our friend too, because it potentially offers a way to diagnose the disease without using invasive nasal swabs.
Why Saliva Tests Could Offer A Better Alternative To Nasal COVID-19 Swabs
Image: Shutterstock Saliva is one of our biggest foes in the COVID-19 pandemic, because of its role in spreading the virus. But it could be our friend too, because it potentially offers a way to diagnose the disease without using invasive nasal swabs.
Keep your nose out of it: why saliva tests could offer a better alternative to nasal COVID-19 swabs
Saliva is one of our biggest foes in the COVID-19 pandemic, because of its role in spreading the virus. But it could be our friend too, because it potentially offers a way to diagnose the disease without using invasive nasal swabs.
Keep your nose out of it: why saliva tests could offer a better alternative to nasal COVID-19 swabs
Wed May 20 Written by Pingping Han, Postdoctoral Research Fellow, The University of Queensland Saliva is one of our biggest foes in the COVID-19 pandemic, because of its role in spreading the virus. But it could be our friend too, because it potentially offers a way to diagnose the disease without using invasive nasal swabs.
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