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Articles

Inspiring, shaping and sustaining an African research & development agenda

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By Mosoka P Fallah, Misaki Wayengera, Isaac F Adewole, Nebiyu Dereje, Elvis Temfack, Tamrat Shaweno, Alemayehu Duga, Nereah Kisera, Monique Wasunna, Bernhards Ogutu, Yaw Adu-Sarkodie, Alhaji U. N’jai, Dougbeh Chris Nyan, Chacha Mangu, Tajudeen Raji, Placide Mbala, Jean-Jacques Muyembe, Nelson K Sewankambo, Jean Kaseya, Moses Bamatura, Cathy A. Tabaro, Farisai Kuonza, Betelhem I. Tekle, Abigael Abiy Mesfin, Peter S. Nyansulu, Ansumana Rashid
| Nature Verified
Why Africa needs regional R&D hubs for basic science and translation research to accelerate local manufacturing. Africa’s vulnerability during global health emergencies — from delayed access to COVID-19 vaccines to the absence of diagnostics, therapeutics or vaccines during the 2026 Ebola outbreak — has made one reality unmistakable: without its own end-to-end research and development (R&D) capacity, the continent will remain structurally dependent and dangerously exposed.
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MVA-BN monkeypox vaccine safety in a clinical trial in the Democratic Republic of the Congo

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By Tyler Bonnett, Gail E. Potter, Laurens Liesenborghs, Olivier Tshiani Mbaya, Veronique Nussenblatt, Placide Mbala, Susan Vogel, H. Clifford Lane, Lori E. Dodd, Nsengi Ntamabyaliro, Emily Yox, Tarcisse Kapene Kilara, Aline Biongo Engo, Emmanuella Muhima, Percy Velela, Laetitia Itunime, Jean-Luc Biampata, Mariano Lusakibanza, Michael Kombozi Basika, Gaston Tona, Jean-Jaques Muyembe
| Nature Verified
Abstract The MVA-BN vaccine is considered safe and effective and has been widely deployed to prevent monkeypox. However, safety and tolerability data from endemic areas are limited. We performed a single-arm clinical trial of the safety of the MVA-BN vaccine among adults in the Democratic Republic of the Congo (ClinicalTrials.gov: NCT05734508; Registered 21 February 2023).
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Mpox emergence, epidemiology, biology, clinical features and control

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By Dimie Ogoina, Jake Dunning, Inger K. Damon, Placide Mbala, Krutika Kuppalli
| Nature Verified
Abstract Mpox, a zoonotic orthopoxvirus disease, has transitioned from a rare infection confined to African rainforests to a global public health threat. Originally identified in laboratory monkeys in 1958, the first human case was documented in 1970 in the Democratic Republic of Congo.
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