Placide Mbala

Abstract The MVA-BN vaccine is considered safe and effective and has been widely deployed to prevent monkeypox. However, safety and tolerability data from endemic areas are limited. We performed a single-arm clinical trial of the safety of the MVA-BN vaccine among adults in the Democratic Republic of the Congo (ClinicalTrials.gov: NCT05734508; Registered 21 February 2023).

Abstract Mpox, a zoonotic orthopoxvirus disease, has transitioned from a rare infection confined to African rainforests to a global public health threat. Originally identified in laboratory monkeys in 1958, the first human case was documented in 1970 in the Democratic Republic of Congo.

Abstract Cholera remains a significant public health burden in many countries in sub-Saharan Africa, though the exact mechanisms of bacterial emergence and spread remain largely undefined. We generated genomic data from 763 Vibrio cholerae O1 isolates predominantly collected between 2019-2024 to create the largest dataset of V. cholerae genomes sequenced locally in Africa.