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Pragney Deme

As seen in: Nature, Frontiers, BioRxiv, Cell Press, Neurology
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Articles

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

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By Yang Liu Verified, Zhiyuan Huang, Yu-Wen Hsu, Pragney Deme, Ashley M Frankenfield, Xiaofeng Zhao, Honghe Liu, Tao Zhang, Elizabeth Alexander, Mingming Liu, Yanjun Zhang, Haocheng Wang, Yixin Zhou, Mervyn J. Monteiro, Norman J. Haughey, Jiou Wang, Suheng Wu
| Nature Verified
Abstract Protein homeostasis and lipid metabolism are essential processes frequently disrupted in neurodegenerative diseases. However, their mechanistic intersection in disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) remains unclear. Ubiquilin 2 (UBQLN2) is a protein quality control factor linked to ALS/FTD.
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A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion

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By Anna Flury, Leen Aljayousi, Hye-Jin Park, Mohammadparsa Khakpour, Jack Mechler, Siaresh Aziz, Jackson D. McGrath, Pragney Deme, Colby Sandberg, Fernando González Ibanez, Olivia Braniff, Thi Chinh Ngo, Simira Smith, Matthew P. Velez, Denice Ramirez Verified, Dvir Avno
| Cell Press Verified
1Neuroscience Initiative, Advanced Science Research Center, The City University of New York (CUNY) Graduate Center, New York, NY 10031, USA 2Graduate Program in Biology, CUNY Graduate Center, New York, NY 10016, USA 3Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C4, Canada 4Graduate Program in Biochemistry, CUNY Graduate Center, New York, NY 10016, USA 5Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Michigan Medicine, Ann...
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PeakClimber: A software tool for the accurate quantification of complex multianalyte HPLC chromatograms using the exponential Gaussian function

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By Joshua T Derrick, Pragney Deme, Norman J. Haughey, Steve Farber
| BioRxiv
Abstract High-performance liquid chromatography (HPLC) is a common medium-throughput technique to quantify the components of often complex mixtures like those typically obtained from biological tissue extracts. However, analysis of HPLC data from complex multianalyte samples is hampered by a lack of tools to accurately determine the precise analyte quantities on a level of precision equivalent to mass-spectrometry approaches.
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