Pralaksha Gurung

Highlights • C. elegans AMsh glia form distinct molecular microdomains of cues around different neurons • Glial KCC-3 localizes only to membranes contacting AFD temperature-sensing neurons • Distal non-AFD neuron cilia repel glial KCC-3 and constrain it to a microdomain around AFD • Glial KCC-3 localization regulates AFD and non-AFD neuron function and associated behaviors Summary Glia interact with multiple neurons, but it is unclear whether their interactions with each neuron are different.

Abstract Proprioception, the sense of self-movement and position, is mediated by mechanosensory neurons that detect diverse features of body kinematics. Although proprioceptive feedback is crucial for accurate motor control, little is known about how downstream circuits transform limb sensory information to guide motor output. Here we investigate neural circuits in Drosophila that process proprioceptive information from the fly leg.

Animals rely on an internal sense of body position and movement to effectively control motor behavior. This sense of proprioception is mediated by diverse populations of mechanosensory neurons distributed throughout the body. Here, we investigate neural coding of leg proprioception in Drosophila, using in vivo two-photon calcium imaging of proprioceptive sensory neurons during controlled movements of the fly tibia.