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Pranatchareeya Chankhamjon on Muck Rack

Pranatchareeya Chankhamjon

As seen in: Color Research & Application, Wiley, Science Magazine, BioRxiv, Cell Press
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Articles

A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules

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By Moamen Elmassry, Kohei Sugihara, Pranatchareeya Chankhamjon, Francine R. Camacho
| BioRxiv
Abstract Changes in the gut microbiome have been associated with several human diseases, but the molecular and functional details underlying these associations remain largely unknown.
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N‐Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase

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By Pranatchareeya Chankhamjon, Kirstin Scherlach, Daniel H. Scharf, Jan Dworschak
| Wiley
Abstract Odd skills: Mutational analysis, in silico studies, and in vitro reconstitution revealed that GliF from A. fumigatus is a novel cytochrome P450 monooxygenase catalyzing an unprecedented N‐heterocyclization reaction to form the hydroindole ring scaffold of the important virulence factor gliotoxin.
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Personalized Mapping of Drug Metabolism by the Human Gut Microbiome

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By Bahar Javdan, Jaime López Verified, Pranatchareeya Chankhamjon, Ying-Chiang J. Lee, Raphaella Hull, Qihao Wu, Xiaojuan Wang, Mohamed S. Donia, Seema Chatterjee
| ScienceDirect Verified
Highlights • Development of subject-personalized ex vivo batch cultures of the gut microbiome • Discovery of diverse drug-microbiome interactions using MDM-Screen • MDM-Screen quantifies drug metabolism by personalized gut microbial communities • Functional genomic and metagenomic screens identify drug-metabolizing enzymes Summary The human gut microbiome harbors hundreds of bacterial species with diverse biochemical capabilities.
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