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Prathapan Thiru

As seen in: PLOS, Genome Biology, BioRxiv, Cancer Cell, Cell Press, Cell Stem Cell
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Articles

Co-transcriptional splicing facilitates transcription of gigantic genes

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By Jaclyn M Fingerhut, Romain Lannes, Troy W Whitfield, Prathapan Thiru
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Fingerhut JM, Lannes R, Whitfield TW, Thiru P, Yamashita YM (2024) Co-transcriptional splicing facilitates transcription of gigantic genes. PLoS Genet 20(6): e1011241. https://doi.org/10.1371/journal.pgen.1011241 Editor: Giovanni Bosco, Geisel School of Medicine at Dartmouth, UNITED STATES Received: April 2, 2024; Accepted: May 31, 2024; Published: June 13, 2024 Copyright: © 2024 Fingerhut et al.
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Co-transcriptional splicing facilitates transcription of gigantic genes

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By Romain Lannes, Prathapan Thiru
| BioRxiv
Abstract Although introns are typically tens to thousands of nucleotides, there are notable exceptions. In flies as well as humans, a small number of genes contain introns that are more than 1000 times larger than typical introns, exceeding hundreds of kilobases (kb) to megabases (Mb). It remains unknown why gigantic introns exist and how cells overcome the challenges associated with their transcription and RNA processing.
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Predicting microRNA targeting efficacy in Drosophila

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By Vikram Agarwal, Alexander O. Subtelny, Prathapan Thiru, Igor Ulitsky
| Genome Biology Verified
To acquire datasets suitable for quantitative analysis of miRNA targeting in fly cells, we monitored the changes in mRNA levels after co-transfecting S2 cells with one of six different miRNA duplexes and a green fluorescent protein (GFP)-encoding plasmid.
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