Edited by: Jinsheng Lai, China Agricultural University, China Zaman, Q.U., Henry, R.J., Mu, Z., Shen, S., Luo, J., and Varshney, R.K. (2026). TADs, CGVs, and compartmentalization in genomes: Providing a new way for crop domestication and improvement. J. Integr. Plant Biol.00: 1– 11. CONFLICTS OF INTEREST The authors declare no conflicts of interest. REFERENCES , , , , and (2023). Idiosyncratic and dose-dependent epistasis drives variation in tomato fruit size. Science 382: 315–320. , and (2008).