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Articles by Qi Long
Histone H4K5 lactylation-driven feedback loop modulates glycerol-linked immunosuppressive activity of tumor-associated T regulatory cells
Abstract Tumor metastasis is the leading cause of death for more than 90% of cancer patients, with colorectal cancer (CRC) mainly spreading to the liver. The colon and liver possess distinct nutritional microenvironments, yet how these differences shape the tumor immune landscape remains unclear. Using single-cell analysis of autologous samples from CRC patients with liver metastases, we identified a distinct CD177+GK+ regulatory T (Treg) cell subset in metastatic lesions.
Generalizable CT vision-language modeling for population health and disease risk
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Abstract Vision-language foundation models (VLMs) for computed tomography (CT) are emerging tools that learn generalizable representations from large-scale clinical imaging data. While these models can predict task-specific labels, the extent to which their representations capture the clinical, physiological, and longitudinal variation of real-world patient populations remains unclear.
By Cameron A. Beeche, Hamed Tavolinejad, Bingxin Zhao, Jessie Dong, Rakesh Sharma Verified, Jeffrey T. Duda, James C. Gee, James Mc Gee, Farouk Dako, Anurag Verma, Colleen Morse, Bojian Hou, Li Shen, Hersh Sagreiya, Christos Davatzikos, Scott M. Damrauer, Marylyn D. Ritchie, Daniel Rader, Qi Long, Eric R. Eaton, Gengwei Zhang, Tianlong Chen, Charles E. Jr., Julio A. Chirinos, Walter R. Witschey, Penn Medicine Biobank, Joonghyun Kim
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Nature
Verified
Real-World Effectiveness of Second-Line Therapies in Advanced Non-Small Cell Lung Cancer: Insights From Propensity-Weighted Comparative Analyses of Longitudinal EHR Data
Faculty, Staff and Student Publications Publication Date 3-1-2026 Journal Clinical Lung Cancer DOI 10.1016/j.cllc.2025.09.010 PubMedCentral® Posted Date 4-20-2026 PubMedCentral® Full Text Version Author MSS Abstract Background: While substantial research has focused on first-line (1L) therapies for advanced-stage non-small cell lung cancer (aNSCLC), less is known about the effectiveness of second-line (2L) treatments following disease progression on 1L.
The compound eye structure, phototactic traits and opsin gene-mediating photosensitive mechanism in Nilaparvata lugens
1 INTRODUCTION Vision is a fundamental sensory modality for insects, playing an indispensable role in key behaviors including survival, reproduction, navigation, and interspecific communication.1-4 Artificial light sources can disrupt various biological processes and alter population structures in insects.5, 6 For instance, exposure to green light can alter the developmental cycle and reduce egg production in the brown planthopper,7 while green light treatment at different developmental...
The role of neuronal protein NOS in regulation of magnetic orientation in the subterranean termite Odontotermes formosanus
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. DATA AVAILABILITY STATEMENT The data that support the findings of this study are openly available in Figshare at https://doi.org/10.6084/m9.figshare.32324172. [dataset] (Wang et al., 2026). Supporting Information Filename Description imb70060-sup-0001-Supinfo.docxWord 2007 document , 55.8 KB Figure S1. Phylogenetic tree of the NOS proteins from O. formosanus and other species. Table S1. Primers used for qRT-PCR.
O-VAD: Industrial Video Anomaly Detection through Object-Centric Tracking and Reasoning
Abstract Industrial Video Anomaly Detection (IVAD) aims to identify anomalous objects and events in an industrial process, which is crucial for modern manufacturing and quality control systems. Existing VLM-based anomaly reasoning methods are capable of detecting open-ended anomalies in general domains. However, their performance declines in industrial settings characterized by intricate object transformations, strict physics, and procedural constraints.
From flash density to field reliability: A population-weighted distance effect model for lightning-induced surge exposure characterization
Charles Zhu, Qiming Zhang, Qi Long, Kael Lan, Kevin Chen , Ethan Zhang, Joyce Xie, Rancho Jiang , Leo Li , Owen Liu, Andy Tam, Farooq Siddiqui Copy BibTeX Lightning-induced surge voltages constitute a primary failure mechanism for outdoor electronic equipment deployed in residential and commercial environments.
A powerful representation learning method for enhanced analysis of incomplete multi-omics data
Abstract Integrative analysis of multi-omics data provides a more comprehensive and nuanced view of a subject’s biological state. However, high-dimensionality and ubiquitous modality missingness present significant analytical challenges. Existing methods for incomplete multi-omics data are scarce, do not fully leverage both modality-specific and shared information, and produce task-biased representations.
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
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Main text (Cell , 2821–2833.e1–e9; May 14, 2026) After online publication, it came to our attention, as the authors, that our paper contained two textual errors in the STAR Methods.
By Shiwei Du, Qi Long, Yanshuang Zhou, Jiangqin Fu, Hao Wu, Yaohang Xie, Yingzhe Ding, Maolei Zhang, Jingyi Guo, Mengfei Wang, Jiajun Lin, Mingli Hu, Jian Zhang, Deyang Yao, Wei Li, FeiXiang Bao, Ge Xiang, Yi Wu, Yile Huang, Haozhao Liang, Rui Wang, Baodan Chen, Chong Li, Junwei Wang, Jiwei Zhang, Dajiang Qin, Jianwei Sun, Yun Zhu, Fei Sun, Wuming Wang, Gang Lu, Wai-Yee Chan, Hui Zhao, Chenli Liu, Xingguo Liu
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Cell Press
Verified
CRP Cutoff Value in East Asians With Coronary Heart Disease: A Systematic Review and Meta-Analysis
Methods This systematic review and meta-analysis adhered the guidelines outlined in the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 statement.18 Supplemental Table 1 contains the PRISMA checklist. The detailed study protocol was registered in advance in the PROSPERO registry (CRD420251064046), guaranteeing transparency and following predetermined methodological processes prior to the commencement of data collection and analysis.
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
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Keywords mitochondria mitochondrial transfer extracellular vesicle mtDNA mutation mitochondrial diseases mtDNA depletion syndrome Parkinson’s disease degenerative disease organelle therapy Get full text access Log in, subscribe or purchase for full access. References 1. Russell, O.M. ∙ Gorman, G.S. ∙ Lightowlers, R.N. ... Mitochondrial Diseases: Hope for the Future Cell. 2020; 181:168-188 2. Ng, Y.S. ∙ Bindoff, L.A. ∙ Gorman, G.S. ...
By Shiwei Du, Qi Long, Yanshuang Zhou, Jiangqin Fu, Hao Wu, Yaohang Xie, Yingzhe Ding, Maolei Zhang, Jingyi Guo, Mengfei Wang, Jiajun Lin, Mingli Hu, Jian Zhang, Deyang Yao, Wei Li, FeiXiang Bao, Ge Xiang, Yi Wu, Yile Huang, Haozhao Liang, Rui Wang, Chong Li, Junwei Wang, Jiwei Zhang, Dajiang Qin, Jianwei Sun, Yun Zhu, Fei Sun, Wuming Wang, Gang Lu, Wai-Yee Chan, Hui Zhao, Chenli Liu, Xingguo Liu, Baodan Chen
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Cell Press
Verified
Trichoscopic Features and Clinical Risk Factors in Female Pattern Hair
Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 19 Authors Long B, Long Q, Pan W, Chen S, Ye Z , Guo H Received 30 November 2025 Accepted for publication 24 January 2026 Published 10 February 2026 Volume 2026:19 585446 DOI https://doi.org/10.2147/CCID.S585446 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 4 Editor who approved publication: Prof.
[2510.19934] Mitigating Privacy-Utility Trade-off in Decentralized Federated Learning via $f$-Differential Privacy
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Prediction of the Closing Time of UHV Disc Spring Hydraulic Operating Mechanism Circuit Breakers Considering Low-Cycle Fatigue
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Qi Long 1, Xu Yang 1, Keru Jiang 1, Weiguo Li 1, Mingyang Li 1, Mingchun Hou 1, Xiang Peng 1, Dachao Huang 1, Dehua Xiong 2 and Xiongying Duan 2,* 1 EHV Power Transmission Company China Southern Power Grid, Guangzhou 510663, China 2 School of Electrical Engineering, Dalian University of Technology, Dalian 116024, China * Author to whom correspondence should be addressed.
A genetically informed brain atlas for enhancing brain imaging genomics - Nature Communications
Abstract Brain imaging genomics has manifested considerable potential in illuminating the genetic determinants of human brain structure and function. This has propelled us to develop the GIANT (Genetically Informed brAiN aTlas) that accounts for genetic and neuroanatomical variations simultaneously. Integrating voxel-wise heritability and spatial proximity, GIANT clusters brain voxels into genetically informed regions, while retaining fundamental anatomical knowledge.
Prediction of Transformer Residual Flux Based on J-A Hysteresis Theory
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Computer Science > Computer Science and Game Theory
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Controlled Fault Current Interruption Scheme for Improved Fault Prediction Accuracy
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Evaluating generalizability of oncology trial results to real-world patients using machine learning-based trial emulations - Nature Medicine
Abstract Randomized controlled trials (RCTs) evaluating anti-cancer agents often lack generalizability to real-world oncology patients. Although restrictive eligibility criteria contribute to this issue, the role of selection bias related to prognostic risk remains unclear. In this study, we developed TrialTranslator, a framework designed to systematically evaluate the generalizability of RCTs for oncology therapies.
Screening and identification of viruses in termites: behavior‐regulating roles of RcBsV and RcBV
Termites live underground in a social setting having continuous contact with microorganism. However, there is no comparative study on virus diversity and relative abundance between termites, castes and body parts in termites.
Circulating KRAS G12D but not G12V is associated with survival in metastatic pancreatic ductal adenocarcinoma - Nature Communications
Abstract While high circulating tumor DNA (ctDNA) levels are associated with poor survival for multiple cancers, variant-specific differences in the association of ctDNA levels and survival have not been examined.
Filling the gaps: leveraging large language models for temporal harmonization of clinical text across multiple medical visits for clinical prediction
The authors have declared no competing interest. This work was supported in part by National Institutes of Health grants, U01CA274576 and RF1AG063481. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
First Characterization and Regulatory Function of piRNAs in the Apis mellifera Larval Response to Ascosphaera apis Invasion
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
NIR-II Fluorescence and PA Imaging Guided Activation of STING Pathway in Photothermal Therapy for Boosting Cancer Immunotherapy by Theranostic Thermosensitive Liposomes
NIR-II Fluorescence and PA Imaging Guided Activation of STING Pathway in Photothermal Therapy for Boosting Cancer Immunotherapy by Theranostic Thermosensitive Liposomes Qi Long, Yuliang Yang, Fangling Liao, Haoting Chen, Dongyue He, Shengliang Li, Li Pengcheng, Weisheng Guo and Yafang Xiao Abstract Photothermal immunotherapy has shown great potential for efficient cancer treatment.
IJGI | Free Full-Text | Place-Centered Bus Accessibility Time Series Classification with Floating Car Data: An Actual Isochrone and Dynamic Time Warping Distance-Based k-Medoids Method
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
High SOX2 expression is associated with poor survival in patients with newly diagnosed multiple myeloma - Blood Cancer Journal
Dear Editor, Relapse is the leading cause of mortality for patients with multiple myeloma (MM). Novel therapies targeting mechanisms of relapse are urgently needed. SOX2 (sex-determining region-box2) is a stem-cell transcription factor whose expression confers drug resistance, enhanced proliferation, and survival advantage to residual myeloma cells, rendering them capable of tumor initiation and survival after cytoreductive therapy [1].
MISNN: Multiple Imputation via Semi-parametric Neural Networks
arXiv:2305.01794 (stat) Download a PDF of the paper titled MISNN: Multiple Imputation via Semi-parametric Neural Networks, by Zhiqi Bu and 3 other authors Download PDF Submission history From: Zongyu Dai [ view email] [v1] Tue, 2 May 2023 21:45:36 UTC (254 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations (What are Smart Citations?) Code, Data, Media DagsHub Toggle DagsHub (What is...
Temporal and Spatial Change in Vegetation and Its Interaction with Climate Change in Argentina from 1982 to 2015
Open AccessArticle by Qi Long 1, Fei Wang 1,2,*, Wenyan Ge 1,2, Feng Jiao 1,2, Jianqiao Han 1,2, Hao Chen 1,2, Fidel Alejandro Roig 3, Elena María Abraham 4, Mengxia Xie 1 and Lu Cai 1 1 Institute of Soil and Water Conservation, Northwest A&F University, Xianyang 712100, China 2 Institute of Soil and Water Conservation, Chinese Academy of Sciences and Ministry of Water Resources, Xianyang 712100, China 3 Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales (IANIGLA-CONICET),...
The Landscape of Circular RNAs in Cardiovascular Diseases
1. Introduction The incidence of cardiovascular disease (CVD) has been increasing rapidly in recent years, which is the leading cause of death worldwide [1,2]. CVDs are characterized by high morbidity, high disability rate, and high mortality, as well as various complications.
First Identification and Investigation of piRNAs in the Larval Gut of the Asian Honeybee, Apis cerana
Open AccessArticle by Qi Long 1,†, Ming-Hui Sun 1,†, Xiao-Xue Fan 1, Zong-Bing Cai 1, Kai-Yao Zhang 1, Si-Yi Wang 1, Jia-Xin Zhang 1, Xiao-Yu Gu 1, Yu-Xuan Song 1, Da-Fu Chen 1,2, Zhong-Min Fu 1,2,*, Rui Guo 1,2,* and Qing-Sheng Niu 2,3 1 College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, China 2 Jilin Institute of Apicultural Research, Jilin 132000, China 3 Apitherapy Research Institute, Fujian Agriculture and Forestry University,...
Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation - Nature Communications
Abstract Pluripotent stem cells hold great promise in regenerative medicine and developmental biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle intermediates, have been reported to play critical roles in pluripotency. Here we show that TCA cycle enzymes including Pdha1, Pcb, Aco2, Cs, Idh3a, Ogdh, Sdha and Mdh2 are translocated to the nucleus during somatic cell reprogramming, primed-to-naive transition and totipotency acquisition.
CEDAR: communication efficient distributed analysis for regressions
Supporting Information Filename Description biom13786-sup-0001-SuppMat.pdf166.9 KB Web Appendices referenced in Sections 1, 3, 4, 1, 3, 4, 1, 3, 4, and 5 are available with this paper at the Biometrics website on Wiley Online Library. The codes that generate the results of the simulation study are available online; see . biom13786-sup-0002-SuppMat.zip289.8 KB Data S1 REFERENCES , , , B., , & (2016) Deep learning with differential privacy.
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