Qianying Yu

This paper is only available as a PDF. To read, Please Download here. Abstract Background Exosomes have emerged as a vital player in cell-cell communication; however, whether airway epithelial cells (AECs) generated exosomes participate in asthma development remains unknown.

Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3–RXR axis in asthma Jiajia Lv‡1, Wen Su‡1, Qianying Yu‡, Meng Zhang‡, Caixia Di‡, Xiaoliang Lin‡, Min Wu§2 and Zhenwei Xia‡3 From the ‡Department of Pediatrics and Department of Pulmonary & Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China and the §School of Medicine & Health Sciences, Department of Biomedical Sciences, University...

Asthma is thought to be caused by malfunction of type 2 T helper cell (Th2)-mediated immunity, causing excessive inflammation, mucus overproduction, and apoptosis of airway epithelial cells. Heme oxygenase-1 (HO-1) functions in heme catabolism and is both cytoprotective and anti-inflammatory. We hypothesized that this dual function may be related to asthma’s etiology.