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Articles by Qu Chen
Automated JDBC query caching with the AWS Advanced JDBC Wrapper
When read queries dominate your database load, response times slow down and costs climb, even when the underlying data rarely changes. The traditional fix is building a custom cache layer, but that means implementing external cache logic for every query, handling serialization, and keeping the cache consistent with the database. That’s a significant engineering investment that pulls focus away from core business features.
MSCMF-DTB: a multi-scale cross-modal fusion framework for drug–target binding prediction
Abstract Predicting drug–target binding remains a central challenge in computational drug discovery, particularly due to the need for models that jointly capture molecular topology, chemical substructures, and protein sequence dependencies. We propose MSCMF-DTB, an end-to-end deep learning framework supporting both drug–target interaction (DTI) classification and drug–target affinity (DTA) regression.
The trajectory and influencing factors of health-promoting behavior in patients after aortic dissection surgery: a longitudinal study
Abstract Background: Health-promoting behavior are important in improving health outcome indicators for patients after aortic dissection surgery. However, there has been limited research on the trajectory of health-promoting behavior among Chinese aortic dissection patients. Aims: To explore the trajectory of health-promoting behavior in patients after aortic dissection surgery and identify influencing factors.
Horizontal acquisition of prokaryotic hopanoid biosynthesis reorganizes membrane physiology driving lifestyle innovation in a eukaryote - Nature Communications
Abstract Horizontal gene transfer is a source of metabolic innovation and adaptation to new environments. How new metabolic functionalities are integrated into host cell biology is largely unknown. Here, we probe this fundamental question using the fission yeast Schizosaccharomyces japonicus, which has acquired a squalene-hopene cyclase Shc1 through horizontal gene transfer. We show that Shc1-dependent production of hopanoids, mimics of eukaryotic sterols, allows S.
Utilizing Machine Learning Techniques to Predict Negative Remodeling in Uncomplicated Type B Intramural Hematoma
Keywords Type B intramural hematoma Vascular remodeling Machine learning Abbreviations CTA (Computed tomography angiography) CRP (C-reactive protein) DT (Decision tree) GBM (Gradient boosting machine) IMHB (Type B intramural hematoma) KNN (K-nearest neighbors) MLP (Multi-layer perceptron) NLR (Neutrophil-to-lymphocyte ratio) RF (Random forest) SVM (Support vector machine) SHAP (Shapley additive exPlanations) TEVAR (Thoracic endovascular aortic repair) ULP (Ulcer-like disruption) WBC (White...
Optimized Phosphorus Application Under Water Stress Enhances Photosynthesis, Physiological Traits, and Yield in Soybean During Flowering Stage
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Animals
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Probiotic Supplementation Alleviates Corticosterone-Induced Fatty Liver Disease by Regulating Hepatic Lipogenesis and Increasing Gut Microbiota Diversity in Broilers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M - Nature Communications
Abstract Cell surface scavenger receptors contribute to homoeostasis and the response to pathogens and products associated with damage by binding to common molecular features on a wide range of targets. Apoptosis inhibitor of macrophage (AIM/CD5L) is a soluble protein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily that contributes to prevention of a wide range of diseases associated with infection, inflammation, and cancer.
Sodium Hypochlorite (NaClO) Disturbed Lipid Metabolism in Larval Zebrafish (Danio rerio), as Revealed by Lipidomics and Transcriptomics Analyses
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Examining students' self‐regulated learning processes and performance in an immersive virtual environment
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request.
AMMVF-DTI: A Novel Model Predicting Drug-Target Interactions Based on Attention Mechanism and Multi-View Fusion
2. Results and Discussion 2.1. Performance on Human, C. elegans, and DrugBank Baseline Datasets In this work, we used the PyTorch framework for our proposed model training on an NVIDIA RTX 3090 GPU, and we selected area under curve (AUC), recall, and precision as the three main metrics to evaluate the model’s performance.
The combination of metagenome and metabolome to compare the differential effects and mechanisms of fructose and sucrose on the metabolic disorders and gut microbiota in vitro and in vivo
The combination of metagenome and metabolome to compare the differential effects and mechanisms of fructose and sucrose on the metabolic disorders and gut microbiota in vitro and in vivo Qu Chen, Ruochen Ren, Yue Sun, Jing Xu, Hua Yang, Xiaoqiong Li, Yingping Xiao, Jinjun Li and Wentao Lyu Abstract Sucrose and fructose are the most commonly used sweeteners in the modern food industry, but there are few comparative studies on the mechanisms by which fructose and sucrose affect host health.
Structural basis for Fc receptor recognition of immunoglobulin M - Nature Structural & Molecular Biology
Kubagawa, H. et al. Identity of the elusive IgM Fc receptor (FcμR) in humans. J. Exp. Med. 206, 2779–2793 (2009). Article CAS PubMed Central PubMed Google Scholar Akula, S., Mohammadamin, S. & Hellman, L. Fc receptors for immunoglobulins and their appearance during vertebrate evolution. PLoS ONE 9, e96903 (2014). Article PubMed Central PubMed Google Scholar Kubagawa, H. et al. The long elusive IgM Fc receptor, FcμR. J. Clin. Immunol. 34, 35–45 (2014). Article CAS Google Scholar Li, Y. et al.
Altered Storage and Function of von Willebrand Factor in Human Cardiac Microvascular Endothelial Cells Isolated from Recipient Transplant Hearts
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Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer - Nature Communications
Protein expression and purification Full-length IgM pentamer. Human IgM pentamer from myeloma (Jackson ImmunoResearch, RRID: AB_2337048) was purified using a Superose 6 10/300 GL column to remove trace amounts of dimers and hexamers. The protein was concentrated at 1.0 mg/ml in PBS. IgM-Fc monomer and IgG1-Fc. Recombinant human IgM-Fc and IgG1-Fc were based on the extracellular parts of the membrane forms of the immunoglobulins.
Iodide‐Mediated Rapid and Sensitive Surface Etching of Gold Nanostars for Biosensing
Abstract Iodide‐mediated surface etching can tailor the surface plasmon resonance of gold nanostars through etching of the high‐energy facets of the nanoparticle protrusions in a rapid and sensitive way. By exploring the underlying mechanisms of this etching and the key parameters influencing it (such as iodide, oxygen, pH, and temperature), we show its potential in a sensitive biosensing system.
营造自贸港公平竞争环境的域外经验 - Lexology
China, European Union November 30 2020 海南地处我国最南端，西临北部湾与广西、越南相对，东濒南海与台湾对望，东南和南部在南海，与菲律宾、文莱、马来西亚为邻。在中国历史的很长的一段时间里，海南被视为“蛮荒之地”。北宋时期的文人苏轼曾因“乌台诗案”，被贬谪到海南。他在苦中作乐时曾给儿子苏过写信，描述海南当地蚝肉的鲜美，就此为后人留下了“献蚝贴”。而今日的海南，正因它独特的地理位置，作为中国与世界沟通的“一带一路”重要战略支点，将成为新一轮改革开放的窗口，新一轮经济创新的“钦赐之地”。...
Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
Highlights • The latent bioreactive Uaa FSY enables PD-1(FSY) to bind to PD-L1 in covalent mode • PD-1(FSY) enhances the activation of T cells and CAR-T cells more than PD-1(WT) • PD-1(FSY) inhibits tumor growth more potently than PD-1(WT) in immune-humanized mice • FSY enables an affibody to bind to the HER2 receptor on cancer cells covalently Summary Small molecule covalent drugs provide desirable therapeutic properties over noncovalent ones for treating challenging diseases.
Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
Highlights • The latent bioreactive Uaa FSY enables PD-1(FSY) to bind to PD-L1 in covalent mode • PD-1(FSY) enhances the activation of T cells and CAR-T cells more than PD-1(WT) • PD-1(FSY) inhibits tumor growth more potently than PD-1(WT) in immune-humanized mice • FSY enables an affibody to bind to the HER2 receptor on cancer cells covalently Summary Small molecule covalent drugs provide desirable therapeutic properties over noncovalent ones for treating challenging diseases.
Teaching Vibrational Spectra to Assign Themselves
A new paradigm for assigning vibrational spectra is described. Instead of proceeding from potential to Hamiltonian to eigenvalues/eigenvectors/intensities to spectrum, the new method goes ``backwards'' directly from spectrum to eigenvectors. The eigenvectors then ``assign'' the spectrum, in that they identify the basis states that contribute to each eigenvalue.
Quantum and Classical IR Spectra of (HCOOH)2, (DCOOH)2 and (DCOOD)2 using Ab Initio Potential Energy and Dipole Moment Surfaces
The accurate quantum mechanical description of the vibrational dynamics and IR spectra of molecules is illustrated here for the formic acid dimer, (HCOOH)2 and isotopologues (DCOOH)2 and (DCOOD)2 in full dimensionality. The calculations make use of recent full-dimensional ab initio potential energy and dipole moment surfaces and are done with the code MULTIMODE. IR spectra are reported for the three dimers and also compared to available experimental spectra.
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