R. Barnett

Keywords X chromosome inactivation Xist RNA inactive X chromosome XCI maintenance XCI escape genes chromosome structure chromosome compartments topological associated domains allele-specific Hi-C TAD remodeling B cells B cell stimulation Research topic(s) CP: Immunology CP: Molecular biology Introduction X chromosome inactivation (XCI) equalizes X-linked gene expression between the sexes in female placental mammals.

Osteoarthritis (OA) is a common degenerative joint disease characterized by abnormal proliferation of chondrocytes with knee OA as the prominent example. It is accompanied by a decrease in type II collagen (Col II) and proteoglycans, characterized by irregular and cracked cartilage surfaces, as well as joint dysfunction and severe pain [1], [2]. The progression of OA is closely associated with early cartilage damage, which can lead to increased intra-articular friction.