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Articles by R. Jones
Computer Science > Artificial Intelligence
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Vacuum ultraviolet dual-comb spectroscopy
Abstract The optical frequency comb has made a significant impact in precision spectroscopy and on our ability to probe atomic, molecular and, recently, nuclear transitions to further our understanding of their fundamental properties and how their dynamics and complex interactions affect the observed world. To expand the energy scales and types of systems that can be studied, frequency comb sources from terahertz to vacuum ultraviolet frequencies and beyond have been pursued.
Longitudinal health-related quality of life after electrochemotherapy in elderly patients with cutaneous melanoma
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Abstract The incidence of cutaneous melanoma (CM) is increasing among elderly patients, who often present with advanced disease, including cutaneous metastases. Electrochemotherapy (ECT) is a local ablative treatment that enhances chemotherapy uptake via electric pulses. Management in patients aged ≥ 65 years is challenging because of frailty, comorbidities, and reduced tolerance to systemic therapy.
By B. Peric, R. Jones, E. Kis, C. Kunte, T. Muir, S. Sathees Kumar, G. Bertino, D. Mowatt, G. Riva, F. de Terlizzi, R. Blagus, G. Sersa, T. Košuta, S. Milićević, M. Omerzel, M. Tolstrup, AJP Clover, H. Nassabi, A. MacKenzie Ross, P. Matteucci, J. Odili, G. Giorgione, M. Mascherini, F. Russano, S. Carpenè, F. Tauceri, M. Brizio, V. Seccia, S. Chiodi, G. Colavitti
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Nature
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R. Karina Jones - Consumer Watchdog
Karina Jones embarked on a wellness journey that led to a remarkable transformation. In 2014, she made a career change, leaving her medical billing and collections agency to pursue her passion in cosmetology. With a newfound focus on fitness and healthy eating, she dedicated herself to a healthier lifestyle. As a licensed hairstylist and makeup artist, Karina thrived on helping people enhance their appearance and boost their confidence.
Deep Phylogenomic Structure and Microendemism in Baja California Ammotrechidae (Arachnida: Solifugae) Support a Model of Distributed Diversification
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data supporting the findings of this study and associated metadata are available from the Dryad Digital Repository at https://doi.org/10.5061/dryad.6djh9w1gx.
Persistent IFN-I signaling inhibits mitochondrial oxidative metabolism in CD8 + T cells during HIV-1 infection under cART
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Abstract Persistent type I interferon (IFN-I) signaling contributes to immune exhaustion and promotes HIV-1 persistence. While we and others have demonstrated that blocking IFN-I signaling in vivo restores anti-HIV-1 T-cell function and reduces viral reservoirs, the underlying mechanism remains unclear.
By Guangming Li, Fei Luo, Wenwen Bi, Mengmeng Lu, Na Liu, Qiuchen Zhao, Runpeng Han, Hongyu Wang, Jianping Ma, Wenjia Hu, Haisheng Yu, Wei Hou, Yong Xiong Verified, Nilu Goonetilleke, R. Jones, Lishan Su
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Nature
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Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control - Nature Immunology
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Abstract Antiretroviral therapy (ART) interruption typically leads to rapid HIV-1 viral rebound in people with HIV-1. To develop an HIV-1 cure, insight into immunological mechanisms capable of preventing HIV-1 viral rebound is urgently needed. Here, we describe three exceptional post-intervention controllers (PICs) who maintained ART-free virological control for >6.5 years (ongoing), >7.5 years (ongoing) and 2.5 years following administration of broadly neutralizing antibodies.
By Katie Fisher, Giacomo S Frattari, Chloe Naasz, Miriam Rosás-Umbert, Lisa Dietz, Anna Juhl, Rikke Olesen, Mariane H Schleimann, Marie H Pahus, Isik S. Johansen, Merle Henderson, Leah Carrere, Isabelle Roseto, Ce Gao, Xu Yu, Emily J. Fray, Beril Aydin, Jun S. Lai, Francesco Simonetti, Ali Danesh, Itzayana G. Miller, Pilar Mendoza, Julia Niessl, Christian Gaebler, Michael S. Seaman, Daniel Kaufmann, Clara Lehmann, Henning Gruell, Florian Klein, Marina Caskey, Michel C. Nussenzweig, Martin Tolstrup, R. Jones, Jesper D. Gunst, Janet D. Siliciano, Mathias Lichterfeld, Robert F. Siliciano, Ole S. Søgaard, Mauro A. Garcia, Junlin Zhuo, Emma Falling Iversen, Donald Lubbeck
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Nature
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Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones - Nature
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Abstract Clonally expanded CD4+ T-cells harboring rebound-competent HIV persist lifelong during ART1-5. Latency is considered the principal barrier to viral eradication and has resisted pharmacological reversal6,7, yet sustained immune pressure appears to erode reservoirs8-15. Recent advances have yielded glimpses into exceptionally rare reservoir-harboring cells, implicating pro-survival properties in persistence16-18.
By Isabella Ferreira, Alberto Herrera, Tan Huynh, Emily Stone, Noemi Linden, Cristian Ovies, Yanqin Ren, Cíntia Bittar, Ethan Naing, Parul Sinha, Ali Danesh, Eva M Stevenson, Fitty L Liu, Louise Leyre, Elina Wells, Itzayana G. Miller, Marie Canis, Ana Rafaela Teixeira, Susan Moir, Tae-Wook Chun, Colin M. Kovacs, Madeleine S Gastonguay, Shy Genel, Paul Zumbo, Doron Betel, Elias K. Halvas, Guinevere Q. Lee, Rachel Scheck, Marina Caskey, Paul D. Bieniasz, Nathan L. Board, Michel C. Nussenzweig, R. Jones, Virender K. Pal, Shane Vedova, Skylar Shea
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Nature
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Q4ddPCR: a flexible, 4-target assay for high-resolution HIV reservoir profiling - Nature Communications
Abstract Precise and scalable quantification of the intact HIV reservoir is critical for advancing curative strategies. Current reservoir assays, such as the intact proviral DNA assay (IPDA), are limited by quantification failures or misclassification of defective proviruses due to HIV sequence heterogeneity.
HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing - Nature Communications
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Abstract Sialic acid-containing glycans (sialoglycans) on pathological cells interact with Siglecs, glyco-immune checkpoint receptors expressed on myeloid cells, suppressing the cytotoxic functions of these immune cells. Using targeted glycomic analyses and gene editing, we show that HIV infection reprograms the glycosylation machinery of infected cells to increase the expression of the sialoglycan ligands for Siglec-3, −7, and −9.
By Shalini Singh Verified, Lacy M. Simons, Hiroaki Tateno, Paul W Denton, R. Jones, Judd F. Hultquist
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Nature
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On The Potency Assurance Journey, Travelers Need A Road Map
By R. Mark Jones, Simon Walker, and Jeffrey J. Talbot Capturing and quantitating the biological effect of a gene therapy candidate in vitro is the most direct and immediate way to support an in vivo clinical program. As such, analytical potency assessment is a universal requirement by global regulatory authorities to support the advancement of therapies from clinical development to registration.
On The Potency Assurance Journey, Travelers Need A Road Map
By R. Mark Jones, Simon Walker, and Jeffrey J. Talbot Capturing and quantitating the biological effect of a gene therapy candidate in vitro is the most direct and immediate way to support an in vivo clinical program. As such, analytical potency assessment is a universal requirement by global regulatory authorities to support the advancement of therapies from clinical development to registration.
Petrography of phosphates in CI and CY carbonaceous chondrites
INTRODUCTION The CI (“Ivuna-type”) and CY (“Yamato”) carbonaceous chondrite meteorites sample material from carbonaceous (C-type) asteroids that likely delivered water, organics, and other volatile species to the inner Solar System (Alexander et al., 2012; Bates et al., 2020; Cloutis et al., 2012; Morbidelli et al., 2000).
Mineralogical evidence for hydrothermal alteration of Bennu samples - Nature Geoscience
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Abstract Samples of asteroid (101955) Bennu delivered by the OSIRIS-REx mission offer the opportunity to study pristine planetary materials unchanged by exposure to the terrestrial environment. Here we use a combination of X-ray diffraction and various electron microscopy techniques to explore the detailed mineralogy of Bennu samples and determine the alteration history of the planetesimal protolith from which they originated.
By T. J. Zega, T. McCoy, S. Russell, L. Keller, Z. Gainsforth, S. A. Singerling, C. M. Harrison, G. Libourel, B. Prince, A. L. King, M. Portail, L. W. Le, M. Thompson, M. C. Benner, J. J. Barnes, I. J. Ong, Z. Zeszut, L. R. Wardell, H. C. Bates, P. F. Schofield, N. Almeida, T. Salge, L. Seifert, K. Righter, F. E. Brenker, S. A. Eckley, J. P. Dworkin, R. Jones, G. Domínguez, H. Yurimoto, N. Kawasaki, S. Tachibana, V. E. Hamilton, I. A. Franchi, K. T. Tait, N. E. Timms, F. Jourdan, S. Reddy, D. W. Saxey, M. Kontogiannis, J. Najorka, A. N. Nguyen, H. A. Bechtel, K. Bajo, H. Busemann, W. Rickard
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Nature
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The 3.5-Inch View-On Perspective and the Medical Profession
I had just taken off my coat to scrub into a case when my phone buzzed. A cardiologist colleague—frequently thoughtful, always concise—had sent a text: a photo of an electrocardiogram (ECG) and the question, “Does this person need a temporary pacemaker?” At age 54, I now need reading glasses in dim restaurants and for small menus. Viewing this ECG on my phone’s 3.5-inch screen required me to zoom in and pan across each lead, unable to see the whole picture at once.
Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study - Nature Communications
Abstract Novel cellular therapies may enable HIV control or cure. HIV-specific T cells targeting conserved immunogenic protein regions of HIV Gag/Pol and the entirety of HIV Nef, termed HST-NEETs, eliminate HIV infected cells in vitro. Here we enroll seven participants in an open-label, single-arm phase 1 study (NCT03485963) to evaluate the safety (primary endpoint) of two autologous administrations of HST-NEET products without prescribed lymphodepletion.
MR Fingerprinting Predicts Gait Improvement After Lumbar Cerebrospinal Fluid Drainage for Normal Pressure Hydrocephalus
Normal pressure hydrocephalus (NPH) results in gait disturbance, but clinical response to extended lumbar drainage (ELD) of cerebrospinal fluid varies. Noninvasive predictors of response are needed. To determine whether MR fingerprinting (MRF) findings have potential as a quantifiable biomarker for predicting clinical response to ELD in patients with NPH.
Iron and copper sulfides in asteroid (162173) Ryugu: Formation conditions and a comparison to the CI and CY chondrites
INTRODUCTION Carbonaceous (C-type) asteroids likely played a key role in the delivery of volatiles to the terrestrial planets, and understanding their formation and evolution is an important step toward constraining the distribution of water and organics in the solar system (Alexander, 2017; Alexander et al., 2012; Morbidelli et al., 2000).
Curation and classification procedures for the UK Antarctic meteorite collection
INTRODUCTION Meteorites are the main naturally delivered source of sizeable pieces of material from beyond the Earth, providing invaluable evidence of how the Solar System formed and evolved.
Atomic frequency standard based on direct frequency comb spectroscopy
We have developed a high performance atomic frequency standard based on Doppler-free direct frequency comb excitation of a two-photon transition in 87Rb. We demonstrate equivalent performance compared to an identical system based on cw laser excitation of the clock transition. This approach greatly simplifies optical clock architecture and eliminates the need for cw lasers in many two-photon frequency standards.
Analysis of image formation in optical palpation
BCS breast-conserving surgery CBOP camera-based optical palpation CFE-OP coherence function-encoded optical palpation FEA finite element analysis FWHM full width at half maximum OCE optical coherence elastography OCT optical coherence tomography OCT-OP optical coherence tomography-based optical palpation OP optical palpation RMSE root mean squared error SOP stereoscopic optical palpation 1 INTRODUCTION In optical elastography, light is used to measure the mechanical properties of tissue,...
HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy - Nature Communications
Abstract The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably integrated provirus. Previous studies characterizing the proviral landscape, which have been predominantly conducted in males in the United States and Europe living with HIV-1 subtype B, have revealed that most proviruses that persist during antiretroviral therapy (ART) are defective.
Numerical and Techno-Economic Analysis of Batch Annealing Performance Improvements in Tinplate Manufacturing
3. Results The results of the transient CFD modelling of the current furnace case and the four improvement proposals are demonstrated in this section. The results are then compared on the basis of the coil temperatures and temperature uniformity reached at the end of soaking inside coil 3, in order to determine promising options for batch annealed steel product quality enhancement.
Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial - Nature Medicine
Abstract Inducing antiretroviral therapy (ART)-free virological control is a critical step toward a human immunodeficiency virus type 1 (HIV-1) cure. In this phase 2a, placebo-controlled, double-blinded trial, 43 people (85% males) with HIV-1 on ART were randomized to (1) placebo/placebo, (2) lefitolimod (TLR9 agonist)/placebo, (3) placebo/broadly neutralizing anti-HIV-1 antibodies (bNAbs) or (4) lefitolimod/bNAb. ART interruption (ATI) started at week 3.
Neurosymbolic Models for Computer Graphics
Abstract Procedural models (i.e. symbolic programs that output visual data) are a historically-popular method for representing graphics content: vegetation, buildings, textures, etc. They offer many advantages: interpretable design parameters, stochastic variations, high-quality outputs, compact representation, and more. But they also have some limitations, such as the difficulty of authoring a procedural model from scratch.
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity - Nature Communications
Abstract In simian-human immunodeficiency virus (SHIV)-infected non-human primates, broadly neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To determine whether this phenomenon also occurs in humans we measured HIV-1-specific cellular immunity longitudinally in individuals with HIV-1 starting antiviral therapy (ART) with or without adjunctive bNAb 3BNC117 treatment.
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial - Nature Medicine
Abstract Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce antiretroviral therapy (ART)-free virologic control have largely been unsuccessful.
SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells - Nature Communications
Abstract Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by CD8+ cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral therapy (ART)-treated individuals have shown increases in HIV transcription, but without reductions in virologic measures, or evidence that HIV-specific CD8+ T-cells were productively engaged.
Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other viruses
Re-emergence of HIV after stopping therapy. Nature. 1999; 401: 874-875 Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells. J. Clin. Invest. 2017; 127: 2689-2696 Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir. PLoS Pathog. 2017; 13e1006283 HIV-1 integration landscape during latent and active infection. Cell. 2015; 160: 420-432 Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells.
Dual-comb absorption spectroscopy of molecular CeO in a laser-produced plasma
Abstract Broadband and high-resolution absorption spectra of molecular cerium oxide (CeO) are obtained in a laser-produced plasma using dual-comb spectroscopy. Simultaneous measurements of Ce and CeO are used to probe time-resolved dynamics of the system. A spectral resolution of 1.24 GHz (2.4 pm) over a bandwidth of 378.7–383.7 THz (781.1–791.5 nm) allows simultaneous detection of hundreds of closely spaced rotational transitions in complex CeO bands.
The Key to Bringing DeFi to the Masses May Lie in NFTs
By R. Quincy Jones The last few years have seen massive growth and adoption in the Decentralized Finance (DeFi) ecosystem. From almost nothing in 2018, DeFi has grown to more than $200 billion in Total Value Locked (TVL) across the wide variety of projects represented in the space. Ethereum alone services over 4 million users, seeing a whopping 8x growth just in 2021.
Opinion: Real-World Use Cases for NFTs in Finance and Trade
Everywhere you look, from the art world to major businesses and even high profile celebrity merchandise, NFT technology is poised to change the nature of digital ownership forever. However, behind the fanfare of owning digital items is a much bigger and more important picture. NFTs are on the verge of completely revolutionizing trade finance and global commerce.
The Cardiff paediatric laryngoscope blade: a comparison with the Miller size 1 and Macintosh size 2 laryngoscope blades*
The view during laryngoscopy is greatly influenced by the patient's anatomy. There is a considerable change in airway anatomy from birth to puberty, and this has influenced the design of equipment and the techniques used for laryngoscopy in the paediatric population. The neonate and infant have the following characteristics: a large head, a relatively large tongue in a small mouth and a mandibular angle of 140°.
The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary TCM Cell Model of Latency
Genome Replication and Regulation of Viral Gene Expression Indra Sarabia, Szu-Han Huang, Adam R. Ward, R. Brad Jones, Alberto Bosque Guido Silvestri, Editor DOI: 10.1128/JVI.01297-20 ABSTRACT The establishment of HIV-1 latency has hindered an HIV-1 cure. “Shock and kill” strategies to target this reservoir aim to induce the latent provirus with latency-reversing agents (LRAs).
Burst-mode dual-comb spectroscopy
Abstract We introduce a new, to the best of our knowledge, modality of dual-comb spectroscopy (DCS) that enables a simplified and powerful new approach for time-resolved measurements with increased acquisition rates. This “burst mode” form of DCS relies on the multiplexing of each probe pulse into a short train of pulses.
Are You Conflicted About Conflict?
If you have a short temper, dealing with conflict graciously can be a daunting challenge. The way you treat people affects your friendships, romantic relationships, career contacts, job security, and even your spiritual life. I’ve been reading and studying about conflict, as well as engaging in a fair bit of it myself, and here are some of the things I’ve learned… Step out of your own shoes. Analyze the situation objectively as it will allow you to truly see both sides of the story.
The Intact Non-Inducible Latent HIV-1 Reservoir is Established In an In Vitro Primary TCM Cell Model of Latency
Genome Replication and Regulation of Viral Gene Expression Indra Sarabia, Szu-Han Huang, Adam R. Ward, R. Brad Jones, Alberto Bosque DOI: 10.1128/JVI.01297-20 Abstract: The establishment of HIV-1 latency has hindered an HIV-1 cure. “Shock and Kill” strategies to target this reservoir aim to induce the latent provirus with latency reversing agents (LRAs).
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA)
Abstract The Intact Proviral DNA Assay (IPDA) was developed to address the critical need for a scalable method for intact HIV-1 reservoir quantification. This droplet digital PCR-based assay simultaneously targets two HIV-1 regions to distinguish genomically intact proviruses against a large background of defective ones, and its application has yielded insights into HIV-1 persistence. Reports of assay failures however, attributed to HIV-1 polymorphism, have recently emerged.
473 Diabetes is an Independent Predictor of Sudden Cardiac Death Following Liver Transplantation: Results From the Australian And New Zealand Liver Transplant Registry Over 30 Years
Assessment of cause-specific mortality following liver transplantation (LT) has demonstrated a preponderance of sudden cardiac death (SCD). The incidence and predictors of SCD following LT has not been studied.
When Cell Phones Cross Borders: Protecting Employees' Sensitive Data From Suspicionless Cell Phone Searches At International Airports
Mondaq Ltd requires you to register and provide information that personally identifies you, including your content preferences, for three primary purposes (full details of Mondaq’s use of your personal data can be found in our Privacy and Cookies Notice): Mondaq hopes that our registered users will support us in maintaining our free to view business model by consenting to our use of your personal data as described below. Mondaq has a "free to view" business model.
VECSEL-based virtually imaged phased array spectrometer for rapid gas phase detection in the mid-infrared
Robert Rockmore, Ricky Gibson, Jerome V. Moloney, and R. Jason Jones Author Affiliations Robert Rockmore,1,* Ricky Gibson,2 Jerome V. Moloney,1 and R. Jason Jones1 1College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA 2Air Force Research Laboratory, Sensors Directorate, Wright-Patterson Air Force Base, Dayton, Ohio 45433, USA *Corresponding author: rrockmore@email.arizona.edu Optics Letters Vol. 45, Issue 20, pp.
An NCRI Prostate Cancer CSG Pilot Study Exploring Real-world Clinical Practice of Imaging Modalities Used in Prostate Cancer Across the UK
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Purpose: The availability of novel imaging modalities (NIM) in prostate cancer (PCa) has overtaken the evidence informing their use. The recent EORTC consensus statement on modern imaging recognises the need for large-scale clinical trials of novel imaging [1].
Abstract No. 558 Quantitative comparison of liver tumor perfusion of Yttrium 90 (Y-90) using balloon occlusion versus end-hole microcatheter
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Balloon-occlusion microcatheters are utilized in locoregional therapy in the liver for improved tumor perfusion. However, no quantitative assessment has been performed to date. The goal of this study is to compare tumor perfusion in liver tumors when using balloon-occlusion microcatheter versus a standard end-hole microcatheter for Y90 administration.
Management of Floating Ascending Aortic Thrombus for the Vascular Surgeon
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 A- CTA demonstrating aortic thrombus (dark arrow); B- gross specimen in-vivo and C- ex-vivo Thrombus formation within the ascending aorta is a rare and poorly understood occurrence which may present with peripheral thromboembolic phenomena with devastating outcomes as strokes, limb ischemia, bowl ischemia etc.
Surgical Management for Secondary Aortoduodenal Fistula
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Image 1 Intraoperative image of end-to-end anastomosis between the infrarenal aorta and cryopreserved aortic graft. Image 2 Endoscopic evaluation significant for aortoenteric erosion of end-to-side aortobifemoral bypass. Aortoenteric fistulas (AEFs) are uncommon but life-threatening conditions carrying a high mortality rate.
A Clearing Technique to Enhance Endogenous Fluorophores in Skin and Soft Tissue - Scientific Reports
Abstract Fluorescent proteins are used extensively in transgenic animal models to label and study specific cell and tissue types. Expression of these proteins can be imaged and analyzed using fluorescent and confocal microscopy. Conventional confocal microscopes cannot penetrate through tissue more than 4–6 μm thick. Tissue clearing procedures overcome this challenge by rendering thick specimens into translucent tissue.
Skeletal Stem Cell-Schwann Cell Circuitry in Mandibular Repair
Highlights • Denervation of the mandible impedes bone healing by impairing skeletal stem cells • Bone healing requires Schwann cell paracrine factors for proper stem cell function • Schwann cells and their signaling products rescue denervated mandibular healing Summary Regenerative paradigms exhibit nerve dependency, including regeneration of the mouse digit tip and salamander limb.
Time-resolved dual-comb measurement of number density and temperature in a laser-induced plasma
Yu Zhang, Caroline Lecaplain, Reagan R. D. Weeks, Jeremy Yeak, Sivanandan S. Harilal, Mark C. Phillips, and R. Jason Jones Author Affiliations Yu Zhang,1,2 Caroline Lecaplain,2 Reagan R. D. Weeks,2 Jeremy Yeak,3 Sivanandan S. Harilal,4 Mark C. Phillips,2,3,4 and R. Jason Jones2,* 1Department of Physics, University of Arizona, 1118 E. Fourth Street, Tucson, Arizona 85721, USA 2College of Optical Sciences, University of Arizona, 1630 E.
Phylogenetic Analysis of Mycobacterium tuberculosis Strains in Wales by Use of Core Genome Multilocus Sequence Typing To Analyze Whole-Genome Sequencing Data
Mycobacteriology and Aerobic Actinomycetes R. C. Jones, L. G. Harris, S. Morgan, M. C. Ruddy, M. Perry, R. Williams, T. Humphrey, M. Temple, A. P. Davies Geoffrey A. Land, Editor DOI: 10.1128/JCM.02025-18 ABSTRACT An inability to standardize the bioinformatic data produced by whole-genome sequencing (WGS) has been a barrier to its widespread use in tuberculosis phylogenetics.
High-Resolution History: Downscaling China’s Climate from the 20CRv2c Reanalysis
3. Large-scale drivers: Consistency with lateral boundary conditions Both 20CR-DS and ERAI-DS assume that the PRECIS RCM can accurately reproduce the large-scale circulation, driven by boundary conditions from the driving reanalyses.
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