Rachappa Balkunde

Highlights • Complex changes in trichome patterning are explained by reduced TTG1 GL3 interaction • Mathematical modeling and data constrainment reveal the network structure • Trichome patterning requires an activator-inhibitor and an activator-diffusion mechanism • Trichome patterning requires two pathways activating long- and short-range inhibitors Summary The regular distribution of trichomes on leaves in Arabidopsis is a well-understood model system for two-dimensional pattern formation.

Rachappa Balkunde‡, Layla Foroughi‡, Eric Ewan§, Ryan Emenecker‡, Valeria Cavalli§,¶,‖ and Ram Dixit‡1 ‡Department of Biology and Center for Engineering Mechanobiology, Washington University, St. Louis, Missouri 63130 §Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110 ¶Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, Missouri 63110 ‖Hope Center for Neurological Disorders, Washington University School of...

Rachappa Balkunde1, Layla Foroughi1, Eric Ewan2, Ryan Emenecker1, Valeria Cavalli2 and Ram Dixit1* 1Washington University in St. Louis, United States 2Washington University School of Medicine, United States ↵* Corresponding author; email: ramdixit{at}wustl.edu Author contributions: R.B., L.F., V.C., and R.D. conceptualization; R.B., L.F., R.E., and R.D. formal analysis; R.B., L.F., E.E., and R.E. investigation; R.B., L.F., E.E., and R.E. visualization; R.B., L.F., and E.E. methodology; R.B....