Rafiou Agoro

In April 2018, during my second year of a postdoctoral fellowship at New York University, I and my colleagues submitted an abstract to the American Society for Bone and Mineral Research (ASBMR), which was holding its annual meeting that September in Montreal, Canada.

OpinionOnline nowOpen access The Jackson Laboratory, Bar Harbor, ME 04609, USA Publication History: Published online December 5, 2024 DOI: 10.1016/j.molmed.2024.11.004Also available on ScienceDirect Copyright: © 2024 The Author(s). Published by Elsevier Ltd.

Abstract FGF23 via its coreceptor αKlotho (KL) provides critical control of phosphate metabolism, which is altered in rare and very common syndromes, however the spatial-temporal mechanisms dictating renal FGF23 functions remain poorly understood. Thus, developing approaches to modify specific FGF23-dictated pathways has proven problematic. Herein, wild type mice were injected with rFGF23 for 1, 4 and 12h and renal FGF23 bioactivity was determined at single cell resolution.