Raluca Gordân

Abstract Genomic studies revealed elevated DNA damage and mutation rates at transcription factor (TF) binding sites in UV-linked cancers. While TFs can promote UV-induced mutagenesis by altering both damage formation and repair, these mechanisms have not been systematically characterized across TFs at high resolution.

Abstract Sequence-specific DNA-binding proteins (DBPs) have critical roles in biology and biotechnology and there has been considerable interest in the engineering of DBPs with new or altered specificities for genome editing and other applications. While there has been some success in reprogramming naturally occurring DBPs using selection methods, the computational design of new DBPs that recognize arbitrary target sites remains an outstanding challenge.

Keywords DNA mutagenesis hypermutation transcription factors mutations in transcription factor binding sites DNA replication errors DNA mismatch repair competition with mismatch repair MutSα mutation patterns Get full text access Log in, subscribe or purchase for full access. References 1. Supek, F. ∙ Lehner, B. Scales and mechanisms of somatic mutation rate variation across the human genome DNA Repair. 2019; 81, 102647 2. Sabarinathan, R. ∙ Mularoni, L. ∙ Deu-Pons, J. ...