Peripheral artery disease (PAD) affects an estimated 6% of the global adult population and remains a major contributor to disability, primarily due to ischemia of the lower extremities.1 In its most severe manifestation, chronic limb-threatening ischemia (CLTI), patients may present with rest pain, nonhealing ulcers, or tissue loss, all of which profoundly diminish quality of life.2 PAD is frequently associated with systemic comorbidities, including diabetes mellitus, hypertension,...