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Rhamy Zeid

As seen in: Nature, Cell Press
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Articles

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

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By Shaokun Shu, Hua-Jun Wu, Jennifer Y. Ge, Rhamy Zeid
| Cell Press Verified
Highlights • Synthetic lethal and resistance interactions with BET inhibitors in TNBC • Multiple independent unbiased screens identify the same genes and pathways • CDK4/6 inhibitors and paclitaxel have top synergies with BET bromodomain inhibitors • Deletion of SNF/SWI complex components leads to BET inhibitor resistance Summary BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative breast cancer (TNBC) and other cancer types, but inherent and acquired...
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Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma

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By Matthew Lawlor, Evon Poon, Jaime Reyes, Rhamy Zeid
| Nature Verified
Seeger, R. C. et al. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N. Engl. J. Med. 313, 1111–1116 (1985). Wakamatsu, Y., Watanabe, Y., Nakamura, H. & Kondoh, H. Regulation of the neural crest cell fate by N-myc: promotion of ventral migration and neuronal differentiation. Development 124, 1953–1962 (1997). Tweddle, D. A., Malcolm, A. J., Cole, M., Pearson, A. D. & Lunec, J.
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