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Shaokun Shu

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Articles

Genome-wide screenings identify BAP1 as a synthetic-lethality target with CDK4/6 inhibitors

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By Lianqiang Peng, Emmanuel Cazottes, Danyang Zhou, Mei Feng, Hong liu, Lu Zheng, Yang Liu, Hao Zhuang, Hao Xu, Tingting Zhang, Zhen Wu, Xiaolong Qian, Huikai Li, Tengfei Xiao, Yisheng Pan, Shaokun Shu, Ning Zhang
| Science Magazine Verified
Abstract The nongenetic mechanisms by which cancer cells escape cell cycle inhibition remain inadequately understood. Here, we uncover an epigenetic pathway driving adaptive resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors in hepatobiliary cancers using integrative approach combining genome-wide CRISPR screenings with transcriptional, epigenetic, and proteomic profiling.
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Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury - Nature Communications

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By Jing Ding, Hongkun Wu, Cong Luo, Shaokun Shu, Xue Qiao, Zefeng Wang, Xueguang Lu
| Nature Verified
Abstract Lipid nanoparticles (LNPs) are a promising platform for mRNA delivery. However, their use in inflammatory pulmonary diseases is limited by reactogenicity and suboptimal delivery. Here we develop a non-inflammatory LNP (NIF-LNP) by incorporating ursolic acid, identified from a natural product library, into a biodegradable, cationic phosphoramide-derived LNP formulation.
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UDA-seq: universal droplet microfluidics-based combinatorial indexing for massive-scale multimodal single-cell sequencing - Nature Methods

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By Yun Li Verified, Zheng Huang, Lubin Xu, Guochao Li, Chengwei Yu, Xini Meng, Nan Jiang, Minxian Wang, Shaokun Shu, Feng Zhang, Weiqi Zhang, Guang-Hui Liu, Limeng Chen
| Nature Verified
Abstract The use of single-cell combinatorial indexing sequencing via droplet microfluidics presents an attractive approach for balancing cost, scalability, robustness and accessibility. However, existing methods often require tailored protocols for individual modalities, limiting their automation potential and clinical applicability.
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