Richard Barfield
As seen in:
PLOS,
Science Magazine,
BioRxiv,
JD Supra,
medRxiv,
The UK in a Changing Europe,
Byline Times
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Maternal Antibodies to Primary CMV Infection Link to Fetal Transmission
S.R.P. serves as a consultant for Pfizer, Merck, Moderna, Dynavax, and Kamada and has led sponsored research programs with Moderna, Pfizer, Dynavax, and Kamada on CMV vaccine development. B.L.H. has received payments from UpToDate and Moderna. G. K. S. is a DSMB member for the Moderna RSV vaccine trial in pregnancy and is an author and contributor to UpToDate. All other authors have no conflicts to disclose.
Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption
Editor’s summary To test whether a therapeutic approach for HIV infection could be curative, people living with HIV need to undergo an analytical treatment interruption (ATI) where they stop taking antiretroviral therapy (ART). Although adults can volunteer for such studies, they are ethically tricky to conduct in pediatric populations. Here, Obregon-Perko et al. asked whether a preclinical pediatric nonhuman primate model might offer insights into features associated with viral control.
The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques
Editor’s summary Congenital cytomegalovirus (cCMV) infections are a major driver of birth defects and neurodevelopmental delays in human newborns. Thus, strategies to prevent transplacental mother-to-fetus transmission are urgently needed. One proposed strategy is to vaccinate against the viral pentameric complex (PC), a multiglycoprotein complex required for viral entry into nonfibroblast cells in tissue culture. Here, Wang et al.
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