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Riikka E. Mäkitie on Muck Rack

Riikka E. Mäkitie

As seen in: Nature
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Articles

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease

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By Ryan C. Chai, Mischa Lundberg, Bernard Freudenthal, James Smith, Andrew Boughton, Kaitlyn Flynn, Monika Frysz, Weng Hua Khoo, Davide Komla-Ebri, Siobhan E. Guilfoyle, John Logan, Natalie C. Butterfield, Victoria Leitch, Andrea Pollard, Lorenzo Ramos-Mucci, Amaia Vilas-Zornoza, Yunshun Chen, Raymond Yip, Jeremy Er, Siew Zhuan Tan, Michelle McDonald, Scott E Youlten, C. Sergio, Ariel Castro-Martinez, Shelley Young, Elena Y. Skorokhodova, David Evans, Joseph Powell, Christiaan de Leeuw, Adam Ewing, John Eisman, Robert Blank, Tri Giang Phan, Anne K. Lagendijk, Edwin Hawkins, Rebecca McIntyre, Edith Hessel, Jake P. Taylor-King, Emma Duncan Verified, Graham Williams, Peter Croucher, John Kemp, Yuandan Zhang, Alexander P. Corr, Michael R. G. Dack, Riikka E. Mäkitie, Nathaniel Bradford, Horng Lii Oh, Paul A. Baldock, J. H. Duncan Bassett
| Nature Verified
Abstract Musculoskeletal diseases are a major health burden. Development of bone-active therapies has been hindered by limited understanding of the cells and genes that regulate the skeleton. We exploited the value of cross-species analysis and developed single-cell methodologies in skeletal tissues to define the critical endosteal compartment that regulates bone turnover.
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