Pathogenesis and Immunity Nathalie Arbour, Robert Day, Jia Newcombe, Pierre J. Talbot DOI: 10.1128/JVI.74.19.8913-8921.2000 ABSTRACT Human coronaviruses (HCoV) cause common colds but can also infect neural cell cultures. To provide definitive experimental evidence for the neurotropism and neuroinvasion of HCoV and its possible association with multiple sclerosis (MS), we have performed an extensive search and characterization of HCoV RNA in a large panel of human brain autopsy samples.