Robert R. Freimuth

PerspectiveOnline nowOpen access Affiliations & Notes 1Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA 2Harvard Medical School, Boston, MA, USA 3Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, TN, USA 4Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA 5Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA 6Institute for Genomic Health, Icahn School of Medicine at...

CONFLICT OF INTEREST STATEMENT Waddah Arafat reports grant and/or contract funding from the American Cancer Society. Hamid Emamekhoo reports fees for professional activities from Bristol-Myers Squibb, Eisai, and Cardinal Health. Robert R. Freimuth reports grant and/or contract funding from the National Human Genome Research Institute of the National Institutes of Health (R35HG011899). Paul Fu reports fees for professional activities from Amazon Web Services and Exact Sciences. Peter E.

Abstract Polygenic risk scores (PRS) have led to enthusiasm for precision medicine. However, it is well documented that PRS do not generalize across groups differing in ancestry or sample characteristics e.g., age.