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Robin G. Bombardi

As seen in: Nature, Cell Reports
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Articles

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

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By Lauren Williamson, Theron Gilliland, Pramod K. Yadav, Elad Binshtein, Robin G. Bombardi, Nurgun Kose, Rachel Nargi, Rachel Sutton, Clarissa L. Durie, Erica Armstrong, Robert Carnahan, Lauren Walker, Arthur Kim, Julie Fox, Michael S. Diam
| ScienceDirect Verified
Highlights • Potent human anti-EEEV monoclonal antibodies were isolated from an EEEV survivor • Fabs neutralized virus, but bivalent IgG was optimal for neutralization • Antibodies inhibit virus entry by stabilization of virus particles • EEEV-33 (IgG) and EEEV-143 (IgA) protected against aerosolized EEEV challenge Summary Eastern equine encephalitis virus (EEEV) is one of the most virulent viruses endemic to North America.
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Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Binding Protein

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By Jinhui Dong, Robert Cross, Michael Doyle, Nurgun Kose, Viktoriya Borisevich, Krystle N Agans, Rachel Sutton, Karla A. Fenton, Robin G. Bombardi, Thomas W Geisbert, Jarrod J. Mousa, Edward J. Annand, Rachel Nargi, Mahsa Majedi, Walter Reichard
| ScienceDirect Verified
Highlights • Antibodies isolated from a healthy donor with exposure to Hendra receptor binding protein • Antibodies protect against Hendra and Nipah infections in animals • Antibodies recognize diverse conserved sites on the henipavirus receptor binding protein • Antibodies to differing sites neutralize by diverse molecular mechanisms Summary Hendra (HeV) and Nipah (NiV) viruses are emerging zoonotic pathogens in the Henipavirus genus causing outbreaks of disease with very high case fatality...
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High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires

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By Cinque Soto, Robin G. Bombardi, Bystander hyperactivation, Morgan Kozhevnikov
| Cell Reports Verified
Highlights • TCR clonotype sharing between individuals is higher than expected by chance • High-frequency TCR clonotypes are captured using gDNA and mRNA sequencing methods • Shared TCR clonotypes have a higher probability of being generated • Functional annotation for TCR clonotypes can be obtained using GenBank Summary The collection of T cell receptors (TCRs) generated by somatic recombination is large but unknown.
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