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Romualdo Barroso-Sousa on Muck Rack

Romualdo Barroso-Sousa

As seen in: Nature, Wiley Online Library, Therapeutic Advances in Medical Oncology, MDPI, JAMA Oncology, ONCOLOGY journal, Future Medicine, Cancer Treatment Reviews, Clinical Breast Cancer
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Articles

A meta-analysis of single agent and dual immune checkpoint inhibitors in metastatic triple negative breast cancer

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By Phaedon Zavras, Hugo Lara-Martinez, Qi Nie, Ming Li, Zehui He, Julius Kattoula, Roisin M. Connolly, Romualdo Barroso-Sousa, Isaac Chan, Sara M. Tolaney, Sylvia Adams, Vered Stearns, Cesar A. Santa-Maria, Evanthia T. Roussos Torres, Nicole Strossman
| Nature Verified
Abstract Single-agent programmed cell death-1 inhibitors or its ligand (PD-1/PD-L1i) demonstrate low response rates in metastatic triple-negative breast cancer (mTNBC), though a subset of patients may achieve durable responses. Data evaluating combined PD-1/PD-L1i and cytotoxic T-lymphocyte–associated protein 4 inhibition (CTLA-4i) are limited. We performed a meta-analysis evaluating the efficacy of single- and dual-agent immune checkpoint inhibitors (ICI) in mTNBC.
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Role of tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer treated with KEYNOTE-522 in real-world setting

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By Renata Colombo Bonadio, Flávia Cavalcanti Balint, Federico Waisberg, Zenaide Silva de Souza, Débora de Melo Gagliato, Mayana Lopes de Brito, Daniele Assad-Suzuki, Daniela Dornelles Rosa, Laura Testa, María Ferreira, Isadora Martins de Sousa, Matheus de Oliveira Andrade, Mariana Gouveia, Fernanda Madasi, José Bines, Candice Lima Santos, Monique Celeste Tavares, Maira Tavares, Mariana Monteiro, Bruna Zucchetti, Anezka Ferrari, Gilmara Resende, Vanesa López, VANESA lOPEZ, Solange Moraes Sanches, Paulo M Hoff, Romualdo Barroso-Sousa, Constanza Perez de la Puente
| Nature Verified
Abstract Tumor-infiltrating lymphocytes (TILs) are established prognostic and predictive biomarkers in early-stage triple-negative breast cancer (eTNBC), yet their role in patients treated with the KEYNOTE-522 (KN522) regimen remains underexplored.
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Beyond a single disease: review of rare histological subtypes of triple-negative breast cancer with implications for prognosis and treatment

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By Mariana Gouveia, Renata Colombo Bonadio, Romualdo Barroso-Sousa, Kartik Rathi, Uma Krishnamurti, Maryam B. Lustberg, Adriana Kahn, Mohamed Kahila
| Nature Verified
Abstract Triple-negative breast cancer (TNBC) is commonly approached as a single clinical entity despite marked biological heterogeneity. A subset of cases corresponds to rare histologic subtypes that display distinct molecular drivers, immune microenvironments, and clinical behavior. In this Review, we summarize the clinicopathologic and molecular features of rare TNBC histologies and discuss emerging therapeutic vulnerabilities.
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