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Articles by Roy Ummels
LacR and TrxB are key virulence factors involved in pneumococcal meningitis as identified by a genome-wide association study
Abstract Pneumococcal meningitis is the most common form of bacterial meningitis, with high case fatality rates. Bacterial genetics influence disease severity, but the underlying mechanisms remain poorly understood. Here, we evaluated top variants from a genome-wide association study (GWAS) linking Streptococcus pneumoniae genetic variation to disease outcome. Fifteen S.
Structure and dynamics of a mycobacterial type VII secretion system
Abstract Mycobacterium tuberculosis is the cause of one of the most important infectious diseases in humans, which leads to 1.4 million deaths every year1. Specialized protein transport systems—known as type VII secretion systems (T7SSs)—are central to the virulence of this pathogen, and are also crucial for nutrient and metabolite transport across the mycobacterial cell envelope2,3. Here we present the structure of an intact T7SS inner-membrane complex of M. tuberculosis.
Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system
Merel P. M. Damen‡1, Trang H. Phan‡1, Roy Ummels§, Alba Rubio-Canalejas‡, Wilbert Bitter§ and Edith N. G. Houben‡2 ‡Section Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands §Department of Medical Microbiology and Infection Control, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Centers, 1081 HV Amsterdam, The Netherlands ↵2 To whom correspondence should be addressed.
Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system
Merel P.M. Damen1, Trang H.
Protease domain and transmembrane domain of the type VII secretion mycosin protease determine system-specific functioning in mycobacteria
Vincent J. C. van Winden‡, Merel P. M. Damen§, Roy Ummels‡, Wilbert Bitter‡,§ and Edith N. G.
Protease and transmembrane domain of the type VII secretion mycosin protease determine system-specific functioning in mycobacteria
Vincent J.C. van Winden1, Merel P.M. Damen2, Roy Ummels3, Wilbert Bitter4 and Edith N.G. Houben2* 1VU University Medical Center, Netherlands 2Vrije Universiteit Amsterdam, Netherlands 3Medical microbiology, VUmc, Netherlands 4VU university / VU university medical center, Netherlands ↵* Corresponding author; email: e.n.g.houben{at}vu.nl Author contributions: V.J.v.W., W.B., and E.N.H. conceptualization; V.J.v.W. and E.N.H. formal analysis; V.J.v.W., M.P.D., and R.U. investigation; V.J.v.W....
Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose
The cell envelope of mycobacteria is a highly unique and complex structure that is functionally equivalent to that of Gram-negative bacteria to protect the bacterial cell. Defects in the integrity or assembly of this cell envelope must be sensed to allow the induction of stress response systems. The promoter that is specifically and most strongly induced upon exposure to ethambutol and isoniazid, first line drugs that affect cell envelope biogenesis, is the iniBAC promoter.
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