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Royce Zhou

As seen in: Science Magazine, BioRxiv, Cell Press, Cell Reports
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Articles by Royce Zhou

FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry

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By Jennifer M Umhoefer, Maya M. Arce, Sivakanthan Kasinathan, Sean Whalen, Rama Dajani, Sanjana Subramanya, Laine E. Goudy, Julia A. Belk, Royce Zhou, Minh Pham, Wenxi Zhang, Rosmely Hernandez, Carinna Tran, Nikhita Kirthivasan, Jacob W. Freimer, Cody T. Mowery, Vinh Nguyen, Mineto Ota, Benjamin G. Gowen, Dimitre R. Simeonov, Zhongmei Li, Andy Chen, Jacob Corn, Howard Chang, Qizhi Tang, Luke A Gilbert, Ansuman T. Satpathy, Katherine S. Pollard, Alexander Marson, Gemma L. Curie
| Cell Press Verified
Keywords gene regulation enhancers transcription factors T cells CRISPR FOXP3 epigenetics regulatory T cells Introduction Lineage-defining factors are tightly regulated by cis-regulatory elements (CREs) to ensure proper cell-type-specific expression.1,2,3 Genes encoding these factors are often marked with extended regions of chromatin modifications associated with CRE activity.3,4 These “super enhancers” harbor distinct CREs occupied by distinct sets of transcription factors (TFs) and...
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Basal p53 maintains a distinct transcriptional program from irradiated p53 in tissue, including tumor suppressors

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By Royce Zhou, James J. Manfredi, Lois H. Silverman, Ramon Parsons
| BioRxiv
Abstract The significance of p53 and its primary and secondary tumor suppressor programs cannot be overstated. A context- and stress-dependent transcription factor, p53 accumulates to mount its most well-characterized programs in response to a variety of stressors, most notably DNA damage. As cells and tissues never exist in a complete absence of stress, a small amount of p53 exists in cells under physiologic stress, detectable by chromatin immunoprecipitation and sequencing, termed basal p53.
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In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity

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By Royce Zhou, Moray J Campbell, Lois Resnick-Silverman, Ian Leibling
| Cell Reports Verified
Introduction Mutation of the TP53 gene is frequent in human cancer with p53 clearly implicated as a tumor suppressor. 1 When mutants gain new powers: news from the mutant p53 field. , 2 Freed-Pastor W.A. Prives C. Mutant p53: one name, many proteins. , 3 Muller P.A.J. Vousden K.H. Mutant p53 in cancer: new functions and therapeutic opportunities. The p53 protein acts mainly a transcription factor that binds in a sequence-specific manner and activates transcription of target genes.
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Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5

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By Edmund A. Griffin, Philippe A. Melas, Royce Zhou
| Science Magazine Verified
Addiction to cocaine is commonly preceded by experiences with legal or decriminalized drugs, such as alcohol, nicotine, and marijuana. The biological mechanisms by which these gateway drugs contribute to cocaine addiction are only beginning to be understood. We report that in the rat, prior alcohol consumption results in enhanced addiction-like behavior to cocaine, including continued cocaine use despite aversive consequences. Conversely, prior cocaine use has no effect on alcohol preference.
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