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rue Henri Koch

As seen in: The Journal of Biological Chemistry
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Articles

G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions

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By Laura Jenkins, Andy Chevigne, Andrew Tobin, rue Henri Koch
| The Journal of Biological Chemistry Verified
Abstract Human G protein-coupled receptor 35 is regulated by agonist-mediated phosphorylation of a set of five phospho-acceptor amino acids within its C-terminal tail. Alteration of both Ser300 and Ser303 to alanine in the GPR35a isoform greatly reduces the ability of receptor agonists to promote interactions with arrestin adapter proteins.
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