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Shufan Yin

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Articles

Diabetes-induced TREM2–endothelial cell signaling impairs ischemic vascular repair

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By Ruizeng Yang, Naseeb Kaur Malhi, Alessandro Umbach, Yingjun Luo, Muxi Chen, Xiaofang Tang, Dongqiang Yuan, Rahuljeet Singh Chadha, Alonso Tapia, Xuejing Liu, Meirigeng Qi, Marpadga A. Reddy, Jiawei Sun, James Otto, Lu Wei, John P. Cooke, Esak Lee, Rama Natarajan, Shufan Yin, Kevin W. Sou
| Science Magazine Verified
Editor’s summary Diabetes can lead to peripheral artery disease (PAD), and how individual cell types across tissues contribute to disease progression has been difficult to understand. Malhi et al. focused on endothelial cells and macrophages from humans with and without type 2 diabetes to find that triggering receptor expressed on myeloid cells 2 (TREM2) was one of the top genes expressed in mononuclear phagocytes. This expression was associated with increased TREM2 ligands in endothelial cells.
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