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Yingjun Luo on Muck Rack

Yingjun Luo

As seen in: Nature, Science Magazine, BioRxiv, The Journal of Clinical Investigation
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Articles

Diabetes-induced TREM2–endothelial cell signaling impairs ischemic vascular repair

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By Ruizeng Yang, Naseeb Kaur Malhi, Alessandro Umbach, Yingjun Luo, Muxi Chen, Xiaofang Tang, Dongqiang Yuan, Rahuljeet Singh Chadha, Alonso Tapia, Xuejing Liu, Meirigeng Qi, Marpadga A. Reddy, Jiawei Sun, James Otto, Lu Wei, John P. Cooke, Esak Lee, Rama Natarajan, Shufan Yin, Kevin W. Sou
| Science Magazine Verified
Editor’s summary Diabetes can lead to peripheral artery disease (PAD), and how individual cell types across tissues contribute to disease progression has been difficult to understand. Malhi et al. focused on endothelial cells and macrophages from humans with and without type 2 diabetes to find that triggering receptor expressed on myeloid cells 2 (TREM2) was one of the top genes expressed in mononuclear phagocytes. This expression was associated with increased TREM2 ligands in endothelial cells.
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Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

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By Naseeb Kaur Malhi, Yingjun Luo, Xiaofang Tang, Rahuljeet Singh Chadha
| BioRxiv
Abstract Diabetes mellitus (DM) significantly accelerates vascular diseases like peripheral arterial disease (PAD). Endothelial cells (ECs) and macrophages (MΦs) singularly and synergistically are important contributors to DM-associated vascular dysfunction. Single-cell (sc) profiling technologies are revealing the true heterogeneity of ECs and MΦs, but how this cellular diversity translates to cell-cell interactions, and consequentially vascular function, remains unknown.
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Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

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By Naseeb Kaur Malhi, Yingjun Luo, Xiaofang Tang, Rahuljeet Singh Chadha
| BioRxiv
Abstract Vasculopathies occur 15 years earlier in individuals with diabetes mellitus (DM) as compared to those without, but the underlying mechanisms driving diabetic vasculopathy remain incompletely understood. Endothelial cells (ECs) and macrophages (MΦ) are critical players in vascular wall and their crosstalk is crucial in diabetic vasculopathy. In diabetes, EC activation enables monocyte recruitment, which transmigrate into the intima and differentiate into macrophages (MΦ).
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