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Ruolin Cui

As seen in: Nature, Frontiers
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Articles by Ruolin Cui

Dementia-related risk associated with endocrine and targeted therapy strategies in breast cancer: a real-world pharmacovigilance analysis

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By Ruolin Cui, Yulian Yin, Hongfeng Chen
| Frontiers
Abstract Background: In clinical practice, adjuvant endocrine and targeted (ET) therapy strategies for hormone receptor-positive (HR+) breast cancer are constantly evolving. The long-term cognitive impact of such adjuvant treatment on patients remains unclear. Methods: This study mined data from the FDA Adverse Event Reporting System (FAERS) from 2010Q1 to 2025Q2 to examine the relationship between ET therapy strategies and adverse events (AEs) related to dementia.
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4D nucleome landscape reveals dissolution of bipartite active X chromosome in liver cancer development

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By Xiaoli Xie, Delin Tan, Jingyun Mo, Yang Xu, Qingqiang Ni, Ting Liu, Huaiming Wang, Bingjie Chen, Yujia Liao, Yingnan Lin, Wanting Chen, Susu Luo, Qing Lin Fang, Yangyinhui Yu, Jiaying Wang, Hong Chang, Qing Gong, Alfred Sze-Lok Cheng, HuiQing Jiang, Tingting Li, Jia En Wang, Menglan Zhao, Cunjing Zheng, Ruolin Cui
| Nature Verified
Abstract Changes of three-dimensional chromosome organization in cancers are well established, but little focus has been placed on the behaviour of X chromosome (chrX). Here we show that hepatic chrX of male mice exhibits chromosome segregation, which is attenuated during hepatocellular carcinoma (HCC) development.
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