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Ryan Conway Burczak on Muck Rack

Ryan Conway Burczak

As seen in: Nature
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Articles

Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease

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By Pramod Chandrashekar, Sayali Anil Alatkar, Noah Cohen Kalafut, Ting Jin, Chirag Gupta, Xiang Huang, Shuang Liu, Athan Z. Li, PsychAd Consortium, Kiran Girdhar, Georgios Voloudakis, Gabriel Hoffman, Jaroslav Bendl, John F. Fullard, Donghoon Lee, Panos Roussos, Daifeng Wang, Ryan Conway Burczak
| Nature Verified
Abstract Alzheimer’s disease (AD) is highly heterogeneous and driven by diverse molecular and cellular mechanisms. Functional genomics investigates these mechanisms from genetic variants to gene expression and regulation. We performed personalized functional genomics analysis on population-scale single-nucleus RNA-seq data, with cross-cohort validation across multiple cohorts comprising over 1900 individual brains, capturing donor-level cell type interactions and gene regulatory networks.
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