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Articles by Ryan D. Risgaard
Adaptive evolution of gene regulatory networks in mammalian neocortex
Abstract Mammals have evolved a more complex brain, exemplified by the transformation of the single-layer dorsal cortex of excitatory projection neurons (ExNs) in ancestors into a multilayered cerebral neocortex1,2,3,4 enriched with diverse intratelencephalic and extratelencephalic ExN subtypes5,6,7, thereby establishing specialized projection systems that enhance brain connectivity and functionality5,6,7,8.
Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex
Abstract The prefrontal cortex (PFC) is critical for myriad high-cognitive functions and is associated with several neuropsychiatric disorders. Here, using Patch-seq and single-nucleus multiomic analyses, we identified genes and regulatory networks governing the maturation of distinct neuronal populations in the PFC of rhesus macaque. We discovered that specific electrophysiological properties exhibited distinct maturational kinetics and identified key genes underlying these properties.
Multimodal analysis reveals genes driving neuronal maturation in the primate prefrontal cortex
Abstract The dorsolateral prefrontal cortex (dlPFC) is an evolutionarily derived cortical region in primates critical for high-level cognitive functions and implicated in various neuropsychiatric disorders. The cells that compose the dlPFC, especially excitatory and inhibitory neurons, undergo extensive maturation throughout midfetal and late-fetal development, during which critical neurodevelopmental events, such as circuit assembly and electrophysiological maturation of neurons, occur.
Multimodal analysis of neuronal maturation in the developing primate prefrontal cortex
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Brain and Organoid Manifold Alignment (BOMA), a machine learning framework for comparative gene expression analysis across brains and organoids
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Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling
Bayesian analysis of the chronology of life’s emergence and development on Earth suggests that if Earth’s history were repeated, the emergence of intelligence might be a sufficiently rare event that it would not be guaranteed to reoccur. Image credit: NASA Earth Observatory image by Joshua Stevens, using Suomi NPP VIIRS data from Miguel Román, NASA's Goddard Space Flight Center.
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