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Abstract The cerebral cortex is organized along a dominant sensorimotor-to-association (S–A) axis, anchored by modality-specific primary sensorimotor areas at one end and transmodal association areas forming distributed networks that support abstract cognition at the other1,2,3,4,5,6,7,8,9,10,11. The developmental mechanisms shaping this axis remain unclear9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24.
Abstract Mammals have evolved a more complex brain, exemplified by the transformation of the single-layer dorsal cortex of excitatory projection neurons (ExNs) in ancestors into a multilayered cerebral neocortex1,2,3,4 enriched with diverse intratelencephalic and extratelencephalic ExN subtypes5,6,7, thereby establishing specialized projection systems that enhance brain connectivity and functionality5,6,7,8.
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