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Ryan Tingle

As seen in: Daily Mail, Nature, BioRxiv, Cell Press, Matador Network
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Articles by Ryan Tingle

Vaccination elicits HIV broadly neutralizing antibodies in primates

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By Jon M. Steichen, Patrick Madden, Claudia Flynn, Swastik Phulera, Monolina Shil, Oleksandr Kalyuzhniy, Alessia Liguori, Leigh M. Sewall, Christopher A. Cottrell, Krystal M. Ma, Sabyasachi Baboo, Jolene K. Diedrich, Katherine M McKenney, Allan C. deCamp, Diane G. Carnathan, Ivy Phung, Parham Ramezani-Rad, Ester Marina-Zárate, Brian Freeman Verified, Zhenfei Xie, Jeong Hyun Lee, Troy Sincomb, Nicole Phelps Verified, Danny Lu, Diana Goodwin, Ryan Tingle, Nushin Alavi, Jenny Tran, Andy Tran, Daniel Bader, Hannah Voic, Xiaoya Zhou, Grace Pixton, Agnes Walsh, Mariane B. Melo, Torben Schiffner, Facundo D. Batista, Dennis Burton, Darrell J. Irvine, James C. Paulson, John R. III, Gabriel Ozorowski, Andrew Ward, Guido Silvestri, Shane Crotty, William R. Schief, Carolyne Kifude, Yumiko Adachi, Alyne Nascimento, Catherine Sovie
| Nature Verified
Abstract The high antigenic diversity of HIV has been a major obstacle to development of a broadly protective vaccine. Nevertheless, protective HIV broadly neutralizing antibodies (bnAbs) exist and have been proposed as templates for vaccine development1-6.
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Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading

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By Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel Bader, Ryan Lim, Krystal M. Ma, Christopher A. Cottrell, Jon M. Steichen, Liling Xu, Paula M. Villavicencio, Madhav Akauliya, Ja-Hyun Koo, Jacqueline Shen, Alexandra Vernich, Oleksandr Kalyuzhniy, Joel Allen, Ali Albowaidey, Anthony Alicea, Bingxian Chen, Erik Georgeson, Nushin Alavi, Abigail Esposito, Nicole Phelps Verified, Michael Kubitz, Quynh Anh Phan, Alessia Liguori, Thavaleak Prum, Ryan Tingle, Danny Lu, Saman Eskandarzadeh, John Warner, Stephanie R. Weldon, Sunny Himansu, Max Crispin, Usha B. Nair, Sophia Liu, William R. Schief, Facundo D. Batista, Jordan Renae Ellis-Pugh, Hannah Naili, Brendon Kelley, Xiaotie Liu
| Cell Press Verified
Keywords B cell germinal center antibody feedback affinity maturation HIV vaccine sequential immunization plasma cells local antibody pool Introduction Affinity maturation is the fundamental process underpinning the humoral response to infection or vaccination.1,2 Exposure to antigen activates a polyclonal B cell response derived from those cells with B cell receptors (BCRs) meeting a minimum affinity threshold.3 Those with very high initial affinities will differentiate into extrafollicular...
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Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial

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By Xiaohe Lin, Christopher A. Cottrell, Oleksandr Kalyuzhniy, Ryan Tingle
| BioRxiv
W.R.S. is an inventor on patents filed by Scripps and IAVI on the eOD-GT8 monomer and 60mer immunogens. W.R.S. is an employee and shareholder of Moderna, Inc. The other authors have no competing interest to declare. Funder Information Declared NIH National Institute of Allergy and Infectious Diseases (NIAID), UM1 AI144462 Collaboration for AIDS Vaccine Discovery International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Consortium (NAC) and Center Ragon Institute of MGH, MIT and Harvard
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Behind the scenes on a cruise ship — secrets from the crew

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By Ryan Tingle
| Matador Network Verified
During the year I spent working on a cruise ship — traveling throughout the Caribbean, England, and Mediterranean destinations like Italy — a common question guests asked me was, “Do you live on the ship?” “No, sir. I fly in every morning on a helicopter and repel down a ladder just before I rip off my outfit to display my superhero work clothes for Royal Caribbean!” Or so I answered in my head. Even now, people are crazy curious about what life was like aboard a major cruise liner. Did we party?
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