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Ryuzaburo Yuki on Muck Rack

Ryuzaburo Yuki

As seen in: PNAS, The Journal of Biological Chemistry
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Articles

Targeting the splicing factor CWC22 induces mitotic slippage through repression of BubR1 expression and CDK1 activity in cancer cells

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By Ryuzaburo Yuki, Youhei Saito, Yuji Nakayama
| The Journal of Biological Chemistry Verified
Key words CWC22 RNA splicing mitosis cell cycle checkpoint control BubR1 cyclin‐dependent kinase (CDK) mitotic slippage Abbreviations APC/C (anaphase-promoting complex/cyclosome) CESC (cervical squamous cell carcinoma) CIN (chromosomal instability) DMEM (Dulbecco’s modified Eagle’s medium) Dox (doxycycline) EJC (exon junction complex) FBS (fetal bovine serum) FC (flow cytometry) GSEA (gene set enrichment analysis) IB (immunoblotting) IF (immunofluorescence) IR (intron retention) MCC (mitotic...
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A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation

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By Katsuhito Fujiu, Ryuzaburo Yuki, Yumiko Oishi, Yukiteru Nakayama
| PNAS Verified
A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation Yukiteru Nakayama, Katsuhito Fujiu, Ryuzaburo Yuki, Yumiko Oishi, Masaki Suimye Morioka, Takayuki Isagawa, Jun Matsuda, Tsukasa Oshima, Takumi Matsubara, Junichi Sugita, Fujimi Kudo, Atsushi Kaneda, Yusuke Endo, Toshinori Nakayama, Ryozo Nagai, Issei Komuro, Ichiro Manabe Proceedings of the National Academy of Sciences Jun 2020, 202005924; DOI: 10.1073/pnas.2005924117
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Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530

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By Mariko Morii, Sho Kubota, Takuya Honda, Ryuzaburo Yuki
| The Journal of Biological Chemistry Verified
Src-family tyrosine kinases are widely expressed in many cell types and participate in a variety of signal transduction pathways. Despite the significance of Src in suppression of apoptosis, its mechanism remains poorly understood. Here we show that Src acts as an effector for Ku70-dependent suppression of apoptosis. Inhibition of endogenous Src activity promotes UV-induced apoptosis, which is impaired by Ku70 knockdown.
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