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Saad Hannan on Muck Rack

Saad Hannan

Boston
As seen in: Nature, JNeurosci, The Journal of Biological Chemistry
Neuroscientist working on brain inhibition in neurodevelopmental disorders and early life development @Harvard. Views are mine. 🇬🇧🇧🇩
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Articles

Schizophrenia-associated glycoprotein Adamtsl3 regulates perineuronal net formation, maintenance, and adult cortical plasticity

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By Teresa Cramer, Saad Hannan, Mark Bear, Takao K. Hensch, Shiva K. Tyagarajan, Lucie Petre
| Nature Verified
Abstract Perineuronal nets (PNNs) regulate the maturation of parvalbumin-positive (PV+) interneurons during postnatal critical periods and continue to support their function thereafter. Their disruption is implicated in neuropsychiatric disorders such as schizophrenia, yet key endogenous PNN regulators remain unknown. Here, we identify the schizophrenia-associated glycoprotein Adamtsl3 as a PV+ cell-autonomous regulator of PNN integrity.
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Differential Coassembly of α1-GABAARs Associated with Epileptic Encephalopathy

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By Saad Hannan, Charlotte Jones, Aida H.B. Affandi, Marielle Minere
| JNeurosci Verified
Research Articles, Cellular/Molecular Saad Hannan, Aida H.B. Affandi, Marielle Minere, Charlotte Jones, Pollyanna Goh, Gary Warnes, Bernt Popp, Regina Trollmann, Dean Nizetic and Trevor G. Smart Journal of Neuroscience 15 July 2020, 40 (29) 5518-5530; DOI: https://doi.org/10.1523/JNEUROSCI.2748-19.2020 Abstract GABAA receptors (GABAARs) are profoundly important for controlling neuronal excitability.
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Cell surface expression of homomeric GABAA receptors depends on single residues in subunit transmembrane domains

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By 'S Choice, Saad Hannan, Trevor G. Smart
| The Journal of Biological Chemistry Verified
Cell surface expression of type A GABA receptors (GABA Rs) is a critical determinant of the efficacy of inhibitory neurotransmission. Pentameric GABA Rs are assembled from a large pool of subunits according to precise co-assembly rules that limit the extent of receptor structural diversity.
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