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Yin Yuan

As seen in: Nature, Wiley, Wiley Online Library, MDPI, Taylor & Francis Online, ACS Publications, Journal of Translational Medicine, Science Magazine, Royal Society of Chemistry, Canadian Journal of Infectious Diseases & Medical Microbiology and
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Articles

Determining the molecular and physiological actions of subtype-selective nanobodies of GABA A receptors

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By Guobin Yu, Ruoqi Liu, Sulin Liu, Chloe S. Chernoff, Martin S. Mortensen, Charlotte Jones, Vikram Babu Kasaragod, Wan-Na Chen, Saad Hannan, Alexander Dunn, Asma Soltani, Richard Turner, Yin Yuan, Ayla A. Wahid, Steven W. Hardwick, Suzanne Scott, Dimitri Y. Chirgadze, Jan Steyaert, A. Radu Aricescu, Jose Enrique Gonzalez-Prada, Chuhan Shang, Damian P. Bright, Stephanie Nestorow, Jianchong Zhou, Natasha M. Duggan
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract γ-Aminobutyric acid type-A (GABAA) receptors are the principal mediators of inhibitory neurotransmission in the human central nervous system.
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Parental Helicopter Parenting Profiles and Adolescent Depression: The Mediating Role of Basic Psychological Needs

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By Yuqing Wu, Yin Yuan, Zhen Wang
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description fare70319-sup-0001-Supinfo.docxWord 2007 document , 244.1 KB Appendix S1: Wording overlap between the depression and basic psychological needs scales.
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ISGylation-mediated stabilization of CYP4Z1 fuels breast cancer initiation and progression

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By Yin Yuan, Yu Lu, Xuedan Han, Yidong Zhang, Qianqian Guo, Hong Yao, Qiyi Yu, Xinting Huang, Hongqi Wang, Miaomiao Niu, Jun Yin, Haibo Rong, Lei Huang, Xiaoman Li, Shengtao Xu, Lufeng Zheng, Manzhen Zhou
| Nature Verified
Abstract Tumor-initiating cells (TICs) are central to cancer progression and metastasis; however, they remain challenging to target therapeutically. Here, using a breast-specific CYP4Z1-transgenic MMTV-PyMT mouse model, we show that CYP4Z1 notably accelerates tumor initiation, enlarges tumor size, promotes metastasis, and expands TIC populations. Multi-omics analyses reveal that CYP4Z1+ epithelial cells exhibit enhanced stemness and reduced differentiation compared with CYP4Z1− counterparts.
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