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Abstract In solid tumors, hypoxia is a key driver of metastasis by promoting cellular plasticity and chromosomal instability (CIN). Despite this, the mechanisms by which malignant cells concurrently co-opt these elements of hypoxic adaptation to promote metastasis remains unclear. Here we report that hypoxia promotes metastasis by suppressing the JmjC-containing histone lysine demethylase KDM8.
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