Sam Sheppard
London
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Articles by Sam Sheppard
UK wind power reaches historic 30GW milestone
by: Sam Sheppard The UK has today (Aug 28) hit a historic milestone of 30 gigawatts (30,000 megawatts) of wind generation capacity. The opening of SSE Renewables' Viking Wind Farm on the Shetland Islands boosted the country's capacity by 443MW, taking the total past the 30GW threshold. Total operational capacity of combined onshore and offshore wind in the UK now stands at 30,299MW, as tracked by RenewableUK's EnergyPulse, the industry'smarket intelligence service.
PeekaPets Bunny Soft Toy
Product Tested By Hannah Godfrey – Alfie 6 Months Hannah Awarded The PeekaPets Bunny 5/5 I knew Alfie would love the bunny as we had just started doing peek a boo with him. He watched me open the bunny and got very excited bouncing up and down. I think it’s a great idea and works really well as a cuddly toy. Although Alfie kept grabbing the eyes I wasn’t sure if he was inquisitive or didn’t like them. Alfie built a positive bond and laughed every time we played with the bunny.
Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function
Highlights • During viral infection, inflammatory cytokines induce aerobic glycolysis in NK cells • Ldha expression is critical for clonal expansion of host-protective anti-viral NK and CD8+ T cells • LDHA facilitates NK cell-activating receptor signaling and effector function • NK cells rely on LDHA for their elimination of tumors Summary Natural killer (NK) cells are cytotoxic lymphocytes capable of rapid cytotoxicity, cytokine secretion, and clonal expansion.
Deconvoluting global cytokine signaling networks in natural killer cells - Nature Immunology
Abstract Cytokine signaling via signal transducer and activator of transcription (STAT) proteins is crucial for optimal antiviral responses of natural killer (NK) cells. However, the pleiotropic effects of both cytokine and STAT signaling preclude the ability to precisely attribute molecular changes to specific cytokine–STAT modules. Here, we employed a multi-omics approach to deconstruct and rebuild the complex interaction of multiple cytokine signaling pathways in NK cells.
The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s
NKp46 Is Necessary for TRAIL Surface Expression on NK Cells and ILC1s IL-2 and IL-15 Fail to Upregulate TRAIL on Mature Ncr1−/− NK Cells NKp46 Is Sufficient to Restore TRAIL Surface Expression in Ncr1−/− NK Cells Mature splenic NK cells in wild-type mice do not express TRAIL unless activated in culture in the presence of IL-2 (Tu et al., 2011xSynergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells.
Doctor Who: Twice Upon a Time review - ‘the show regenerates, and not a moment too soon’
In October 1966, the BBC broadcast The Tenth Planet, the last serial featuring the first incarnation of the Doctor. “It’s far from being all over,” the Doctor proclaims near the end, and, not long afterward, viewers were confronted with the unexpected sight of the Doctor regenerating for the very first time. This is the moment which Steven Moffat decides to revisit in Twice Upon a Time, Peter Capaldi’s swansong.
The Paris Climate Accord is now little more than scrap paperDaniel Villar argues that despite being formed with the best intentions, the Paris Climate Accord now serves as a reminder of a collective failure to combat climate changeTrump in Paris. Photo: Wikimedia CommonsWhen faced with the hustle and bustle of daily political life, it’s easy to forget that human civilisation is in a continued state of jeopardy.
A study has found that ethnic minorities graduating from Oxford University have higher starting salaries than white Oxford graduates. The research, by the University Career Service, analysed nearly 3000 graduates and suggested that social background did not impact career prospects after graduating from Oxford. The average starting salary for ethnic minority graduates was found to be £26,000, compared to £19,200 for white graduates.
There is a saying: absence makes the heart grow fonder. In my case, at least, this is untrue; the time I’ve spent in Oxford has only made me realise that I regard my home city with indifference at best. Gloucester is not a particularly exciting place to live. When it comes to culture, heritage or visual appeal, Oxford definitely has the edge.
Weak epistasis may drive adaptation in recombining bacteria
Weak epistasis may drive adaptation in recombining bacteria Brian J Arnold, Michael Gutmann, Yonatan Grad, Sam K Sheppard, Jukka Corander, Marc Lipsitch, William P Hanage bioRxiv 119958; doi: https://doi.org/10.1101/119958
‘Work, Consume, Die’—Will Self and Drifting the Busan Urban Landscape Pt.1 - the3WM
By Sam Sheppard I remember a conversation I had with one of my father’s friends about two years ago, in which he explained to me the fascinating holiday he’d just returned from. Expecting the most opulent of responses, I was somewhat shocked when he responded to my question of where he had visited. He had, in his own words, ‘done London’—a phrase entailing the sampling of museums, art galleries, historical sites, as well as more atypical places of interest.
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