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Articles by Samuel Lim
Iterative computational and rational design generates diverse PET hydrolases for plastic depolymerization
Abstract Evolutionary relationships among homologous enzymes can be leveraged to introduce large numbers of amino acid substitutions for improved functional properties. Here, we combine evolution-informed design (EVdesign) with rational design to engineer improved poly(ethylene terephthalate) (PET) hydrolases (PETases).
Vietnam Critical Illness Data Insights 2018–2024: Key Takeaways for the Market [Infographic]
New Business Demographics: Young, and Evenly Split Across all markets where Gen Re conducts the CI Data Insights Study, the median issue age for CI insurance is typically for people in their 20s. This is not surprising given that this is when insureds start to have some form of earnings after a few years in the workforce and are planning for financial stability. In the Vietnam study this is no different, with the median policy issue age being 28 years.
Malaysia Critical Illness Data Insights 2019–2024: Key Takeaways for the Market [Infographic]
A Growing Market, but Protection Adequacy Remains Important The Malaysian CI market expanded over the study period, with in‑force policies rising from 5.5 million in the 2015–2019 study1 to 6.4 million in the current 2019–2024 study, representing growth of 16%. Average sum assured rose from MYR 83,000 in 2019 to MYR 89,000 in 2024, up about 7%.
AI-Enabled Underwriting 2.0 – Balancing Efficiency, Accuracy, and Trust
AI in Life & Health Underwriting New technology is transforming every aspect of the insurance underwriting processing chain – the massive amounts of data handled by insurers are now being processed and summarised for underwriting by artificial intelligence (AI). AI’s principal impact thus far has been expediting the underwriting process by efficiently gathering, analysing, and summarising data.
Inteligencia actuarial con IA generativa – un marco ilustrado a través de los siniestros de Enfermedades Graves
Muchos debates sobre la IA generativa en el sector de los seguros se centran en la tecnología. Sin embargo, la cuestión más interesante es quién está capacitado para integrarla en nuestro flujo de trabajo, y en este sentido los actuarios cuentan con una ventaja poco común.
Actuarial Intelligence with Generative AI – A Framework Illustrated Through Critical Illness Claims
Many discussions of generative AI in insurance focus on the technology. The more interesting question is who is equipped to embed it in our workflow, and on that count actuaries have an unusual advantage. The discipline already trains its practitioners to take complex, ambiguous problems apart into structured components that can be tested and validated, and to do so with statistical rigour, an emphasis on explainability, and an eye on governance.
514 A NEW BILIO-PANCREATIC BIODEGRADABLE STENT: FIRST U.S MULTICENTER EXPERIENCE WITH COMPARATIVE DATA FROM THE UNITED KINGDOM AND SINGAPORE.
Also available on ScienceDirect
Diabetes and Critical Illness Insurance – Bridging the Protection Gap
Maintaining an active lifestyle is one of the most effective ways to prevent diabetes. Interestingly, Gen Re’s CI study also reveals a strong correlation between cardiovascular incidence rates and Body Mass Index (BMI).7 This reinforces the importance of regular exercise not only to reduce the risk of diabetes but also to lower overall cardiovascular risk. Diabetes & CI Products Diabetes is not just about blood sugar.
Japan’s life sciences and R&D real estate opportunity
Japan is reigniting its innovation engine. Once a powerhouse in global research and development, Japan saw its share of global innovation slip following the 1990s. Today, the government is making a renewed effort to revitalize its R&D landscape. In 2023, Japanese corporates invested more than ¥15 trillion ($102 billion) in R&D, ranking the country third globally — and first among major economies in R&D spend as a share of GDP, surpassing the United States and China.
Reigniting innovation: Japan’s life sciences and R&D real estate opportunity
Japan is reigniting its innovation engine. Once a powerhouse in global research and development, Japan saw its share of global innovation slip following the 1990s. Today, the government is making a renewed effort to revitalise its R&D landscape. In 2023, Japanese corporates invested more than ¥15 trillion (US$102 billion) in R&D, ranking the country third globally — and first among major economies in R&D spend as a share of GDP, surpassing the United States and China.
3 Reasons Why You Should Care About Ancient Rome
3 Reasons Why You Should Care About Ancient Rome A couple of years ago, there was a meme going around on Tiktok. Women would show themselves asking the men in their lives how often they thought about the Roman Empire - it turns out they thought about it pretty frequently. I'm an ancient Rome nerd myself, and in this article I give you 3 reasons why you should give a damn about ancient Rome, even if you're not into history.
Is fantasy fiction childish?
"When I was a child, I spake as a child, I understood as a child, I thought as a child: but when I became a man, I put away childish things." -1 Corinthians 13:11 "When I became a man I put away childish things, including the fear of childishness and the desire to be very grown up." -C.S. Lewis This fairy elf child wonders why grown-ups are so stodgy... her pet dragon says it's because they don't play enough. I was once chatting with a fellow Toastmasters member at a meeting.
The Tao Te Ching bamboozled my brain... I found an explanation for how it works.
The Tao Te Ching is famous for paradoxical statements that contradict logical sense. I think I figured out how it works. Sanjay here has spent 10 years reading the Tao Te Ching and he still doesn't understand it at all. He reports that it is a most excellent tool for when he wants to take a sick day off from work, though - he just reads a chapter and spends a few hours thinking hard about it until he gets a migrane, then he can go see the doctor and get an MC.
3 Reasons Why I Love History
If you know me, you know I'm a big history fan. Here are 3 big reasons why I love history: Amusing anecdotes that are still relatable to us hundreds or thousands of years later. Picture a typical Ming era (1368-1644) porcelein plate. It typically looks like this: Basically, porcelain produced by the imperial kilns at Jingdezhen in Southern China for domestic or imperial use tend to have traditional Chinese motifs like dragons and phoenixes.
How Do We Know Which Religion/Spiritual Teaching Is True?
How Do We Know Which Religion/Spiritual Teaching Is True? As an earnest spiritual seeker, this is the question I’ve been pondering all my life. I was born and raised Christian (Presbyterian denomination), so I’ve been taught that the Bible is the only truth, it is divinely inspired and contains the inspired divine Word of God, if you don’t believe or become a Christian you will go to Hell, the Church’s teachings are correct and are the only true religion etc.
What a 2,200-Year-Old Butcher Can Teach Us About Effortless Mastery
What a 2,200-Year-Old Butcher Can Teach Us About Effortless Mastery Over two thousand years ago, a Taoist text called the Zhuangzi told the story of Cook Ding, a humble butcher who was cutting up an ox for his lord.
FIRST CASE REPORT OF EOSINOPHILIC PSEUDOTUMOR OF THE OESOPHAGUS AND SYSTEMATIC REVIEW OF EOSINOPHILIC PSEUDOTUMORS OF THE LUMINAL GASTROINTESTINAL TRACT
Also available on ScienceDirect
A Quick And Easy Way To Gain Positive Momentum, In Less Than 5 Minutes A Day
Samuel Lim · Follow 3 min read · -- You’re stuck in a funk. Nothing seems to be working. You try very hard, and things seem to be going well at first. But then you start to run out of willpower. Or life starts to take over, and then you end up procrastinating or giving up. You are now back where you started. Except now you feel worse off than before, because in addition to accomplishing exactly nothing, you are a big fat failure. What do you do? I found a quick and easy way to gain positive momentum.
MAS Revises Guidelines on Licensing for Payment Service Providers - New Licence Application Requirements
Executive Summary The Guidelines on Licensing for Payment Service Providers (PG-G01) ("Guidelines") issued by the Monetary Authority of Singapore ("MAS") were revised recently to include new requirements for licence applications under the Payment Services Act 2019 ("PS Act"), including: for all licence applications, a legal opinion assessing how the regulated payment services are applicable to each proposed service or product covered by the applicant's business model; for licence applications...
Enabling high-throughput enzyme discovery and engineering with a low-cost, robot-assisted pipeline
Home Remedies 2 days ago Try These Home Remedies For Bloating For Better Gut Health NDTV - Manya Singh • 2d Here we share a list of home remedies you can try to reduce bloating.
Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures
Abstract Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy. A major focus of human and animal studies on TLE network has been the limbic circuit. However, there is also evidence suggesting an active role of the basal ganglia in the propagation and control of temporal lobe seizures. Here, we characterize the involvement of the substantia nigra (SN) and somatosensory cortex (SI) during TL seizures induced in two nonhuman primates.
Tardigrade secretory proteins protect biological structures from desiccation
Abstract Tardigrades, microscopic animals that survive a broad range of environmental stresses, express a unique set of proteins termed tardigrade-specific intrinsically disordered proteins(TDPs). TDPs are often expressed at high levels in tardigrades upon desiccation, and appear to mediate stress adaptation.
Phase-separated biomolecular condensates for biocatalysis
Highlights Liquid–liquid phase separation drives the formation of droplet-like biomolecular condensates. Multienzymatic cascades have been reconstituted in phase-separated condensates in vitro to allow for efficient cell-free biocatalysis. Synthetic membraneless organelles have been assembled in living cells to compartmentalize heterologous metabolic reactions. Controlling condensate assembly/disassembly and biophysical properties allows dynamic regulation of metabolic pathways in vivo.
MAS Framework for Domestic Systemically Important Insurers (D-SIIs) to Take Effect on 1 Jan 2024
Introduction In October last year, the Monetary Authority of Singapore ("MAS") issued a Consultation Paper on its proposed framework for Domestic Systemically Important Insurers ("D-SIIs") which is intended to formalise and update its Framework for Impact and Risk Assessment of Financial Institutions to facilitate the annual impact assessment of insurers based on their size, interconnectedness, substitutability and complexity.
MAS Announces New Regulatory Framework for Stablecoins
Introduction On 15 August 2023, the Monetary Authority of Singapore ("MAS") released the finalised regulatory framework for stablecoins regulated in Singapore in its "Response to Public Consultation on Proposed Regulatory Approach for Stablecoin-related Activities" ("Response") where MAS responded to feedback received on MAS' earlier public consultation ("Consultation") which was published in October 2022 where MAS first set out its proposals for the new regulatory framework.
MAS Consults on Proposed New Requirements for Digital Payment Token Service Providers to Enhance Investor Protection and Market Integrity
Introduction The Monetary Authority of Singapore ("MAS") is seeking feedback on the following two consultation papers which will introduce legal requirements that aim to enhance investor protection and address market integrity risks in Digital Payment Token ("DPT") services: Consultation Paper on Proposed Amendments to the Payment Services Regulations ("Investor Protection Consultation") Consultation Paper on Proposed Measures on Market Integrity in Digital Payment Token Services ("Market...
Legacy" - Why This New Superman Is Nothing Like Henry Cavill's Version - Hype MY
It has been announced! Actor David Corenswet will officially take up the role of Kal-El / Clark Kent / Superman in James Gunn’s upcoming film “Superman: Legacy”. After the bombshell announcement that Henry Cavill was being dropped from the role, the DC Universe (DCU) fandom was left in a tailspin. We speculated that Gunn might be recasting the role to Tyler Hoechlin from “Superman & Lois”. Then we heard interesting news about how James Gunn’s film would take the character in a whole new direction.
Netflix's "King of Clones" Documentary Review: The Creepy Story Of The Mad Korean Scientist Who Tried To Cloned Humans
In our time reviewing Netflix documentaries, we’ve seen some wild stuff. From strange social experiments revolving around a millionaire dog to creepy South Korean death cults masquerading as churches. There’s no shortage of strangeness to mine within the streaming service’s vast library of shows. Just when we thought we’d seen it all, we come across a story that leaves us utterly shocked and hungry to explore the depths of human depravity.
Marvel's "Secret Invasion": Our Thoughts After Watching Episode 1
After the cosmic adventures of “Guardians of the Galaxy Vol. 3”, the Marvel Cinematic Universe (MCU) is returning back to its Earth roots for a spy thriller. This time, we’re following an aged Nick Fury as he races against time to save the planet from a rogue faction of Skrulls looking to replace key leaders of Earth with their own. This is “Secret Invasion”. Unlike previous MCU TV shows on Disney+, “Secret Invasion” seems to be going for a darker, more grounded take as Fury must wage a shadow war.
5 Disturbing Moments In Disney Animated Films You'll Never See Adapted To Live-Action
Long before Disney was dishing out comic-book films and Star Wars spin-offs, the company was best known for its stellar 2D-animated classics. All you 90s and 2000s kids will surely remember such hits as “The Lion King”, “Mulan”, “The Little Mermaid” and “Beauty and the Beast”. Even though they were marketed towards kids, we always knew there was a special charm and magic to them. Something that adults could look back to one day and remember fondly.
The Flash: Movie Ending, Post-Credits Scene & DCU's Batman Explained
It got nuts, alright! Andrés “Andy” Muschietti’s “The Flash” is now speeding its way into theatres with Ezra Miller helming the film as the titular hero. For those who have had a chance to catch it already, then you may be left with some lingering questions regarding how James Gunn and Peter Safran’s DC Universe (DCU) franchise will be moving forward from here.
"Spider-Man: Across The Spider-Verse": Ending Explained & What To Expect In "Beyond the Spider-Verse"
Well, that was intense! The much-anticipated sequel to 2018’s “Spider-Man: Into the Spider-Verse” is finally here. Along with it came greater expectations for the sequel to ramp up the storytelling, action and general multiversal mayhem. And it did not disappoint, be sure to check out our review for why we think “Spider-Man: Across the Spider-Verse” is the best Spider-Man film since Sam Raimi’s “Spider-Man 2”.
"Across The Spider-Verse" Review: This Masterpiece Is The Darkest & Grandest Spider-Man Story We've Seen!
2018’s “Spider-Man: Into the Spider-Verse” was a major gamble on Sony’s part. Disney gets to parade out their live-action version of the character and you choose to potentially play second fiddle to them by going animation? It could have easily backfired…but it didn’t. Instead, they delivered one of the greatest Spider-Man films of all time; plus winning an Oscar! A fresh, fun, meta-laden rendition of the Spider-Man origin story through the eyes of a young, intercity teen, Miles Morales.
5 Malaysian Politicians Who Deserve A Film Of Their Own
Malaysian politics can often be described as messy, morally grey and even downright filthy! One thing that cannot be denied is that it is highly engaging and entertaining in a sick, twisted sort of way. Since Pakatan Harapan (PH) took over power in 2018, Malaysian politics has seen upheavals that could easily be found in HBO’s “Game of Thrones”. Old rivals teaming up to take down a greater threat. Secret coups and the power struggles that threaten to bring down whole administrations.
Spider-Man: Across The Spider-Verse – How Does The MCU's Multiverse Fit Into Sony's Spider-Verse? - Hype MY
Whether it’s Tom Hardy’s Venom making a cameo in “Spider-Man: No Way Home” or Morbius teasing a team-up with Michael Keaton’s Vulture for a sinister plan, Disney’s Marvel Cinematic Universe (MCU) and Sony’s Spider-Verse are clearly linked in some way.
Top 5 Times PAS Needed To Take A Chill Pill & Relax
Religion. A topic that has never caused any controversy ever in the history of time, right? Well, like it or not, religion is part of the daily lives of millions of Malaysians. Most people in our fair tanah air have found a way to live out their faith in ways that are both beautiful and harmonious. In ways that respect the freedoms and decisions of those outside and within their faith communities. Then of course…there are the religious fundamentalists.
MAS Proposes Amendments to Subsidiary Legislation to Operationalise Revisions to Payment Services Act
Introduction On 8 May 2023, the Monetary Authority of Singapore ("MAS") issued a consultation paper ("Consultation Paper") on proposed amendments to the Payment Services Regulations 2019 ("PSR"), existing notices applicable to payment service providers ("Notices"), and new proposed Regulations on exemptions for a specified period, in order to operationalise the amendments to the Payment Services Act 2019 ("PS Act") that were passed under the Payment Services (Amendment) Act 2021 ("Amendment...
Tenet Review: A Masterpiece That Transcends Cinematic Conventions
It’s been 70 years since the world was introduced to Akira Kurosawa’s legendary crime film, Rashomon. A groundbreaking film that was the first to make use of the idea of non-linear storytelling. Little did Kurosawa know, decades from now, that his experimental narrative device would become the cornerstone of one the greatest filmmakers of the 21st century, Christopher Nolan. A visionary director, a talented writer and a masterful storyteller.
Netflix's "The Mother" Review
If we had a gold coin for every film trying to cash in on the assassin-coming-out-of-retirement craze 2014’s “John Wick” started, we’d have enough to buy the Continental by this point! Really by now, it’s more about the flavour and execution of the worked-to-death narrative than the actual story.
"Harry Potter" TV Show: 5 Character Storylines HBO Could Explore Better Than The Films
Potterheads everywhere were recently greeted with the news that we will be getting an adaptation of the “Harry Potter” books in the form of a new TV series on HBO’s streaming service, Max. With over 20 years since the first film, “Harry Potter and the Philosopher’s Stone”, the series will introduce a whole new cast to bring our favourite characters to life. Yeah, so don’t expect Daniel Radcliffe, Rupert Grint or Emma Watson to be reprising their roles as the lovable trio.
Part Two" - Plot, Characters, Future Films & TV Shows Explained - Hype MY
In 2021, we saw the impossible happen. Visionary director and auteur Denis Villeneuve brought Frank Herbert’s seminal science fantasy novel “Dune” to the big screen in all its visual and narrative glory! Considered to have been the inspiration behind such franchises as “Star Wars” and “Warhammer 40,000”, the story of “Dune” follows the journey of the messiah-to-be Paul Atreides as he watches the fall of his great house at the hands of his enemies.
Guardians Of The Galaxy Vol. 3 Ending, Post-Credit Scenes & New Team Explained
Alas, all good things must come to an end and “Guardians of the Galaxy Vol. 3” marks the conclusion of director James Gunn’s rib-tickling, heart-warming space trilogy! You know, on the count that he has an entire, whole other cinematic universe to manage. In any case, we’re going to miss his unique voice in the Marvel Cinematic Universe (MCU). That being said, in spite of “Guardians of the Galaxy Vol.
James Gunn's "Superman: Legacy" – Why This Version of Superman Is Unlike Anyone Ever Seen Before - Hype MY
While we’re sad to see Henry Cavill leave the stage as this generation’s Superman, the show must go on in the DC Universe (DCU). With “The Flash” set to reboot the entire DCU, Gunn has some major plans for the future of the franchise and it all starts with Superman! In his video announcement, the first film of his new lineup will be “Superman: Legacy”, a film that promises to explore a side of Superman we’ve never seen in cinema before.
Lee Cronin's "Evil Dead Rise": Review, Ending & Creatures Explained
In the world of horror, Sam Raimi’s “Evil Dead” film franchise has always stood as a cinematic landmark when it comes to classic, fun gross-out thrills. The franchise has seen several movements from its quintessential roots as polished and engaging cabin horror films to fun, zany horror comedies with “Army of Darkness” and 2015’s “Ash vs Evil Dead” series.
The Marvels: The Skrulls, Kree Empire & Main Villain Explained
It’s been a wild week for Marvel announcements and among the biggest ones out there is a teaser trailer for this November’s “The Marvels”. Brie Larson is back as the cosmic-powered defender of the universe, Captain Marvel. This time, though, she’s joined by two familiar faces with Teyonah Parris as Monica Rambeau, the daughter of Captain Marvel’s best friend, and Iman Vellani as the adorkable Kamala Khan, or Miss Marvel.
"Lanterns" Series: Plot, Characters & DCU's Next Big Villain Explained
A while back ago, DC Studios CEO James Gunn dropped a major bombshell of an announcement on the DC Universe (DCU) community. As part of his 8 to 10-year plan for the franchise, he announced 5 new films and 5 new TV series that Warner Bros. Discovery are currently developing. Among the 5 new TV shows, Gunn confirmed one revolving around DC’s most iconic team of intergalactic space cops, the Green Lanterns, called “Lanterns”.
Secret Invasion: Why Emilia Clarke's Character Is The Next Nick Fury
With the release of the official trailer for Marvel Studios’ “Secret Invasion”, we learn more exciting details about Nick Fury’s final mission to stop a deadly plot by the Skrulls. We’ve seen the race of shape-shifting aliens here and there within the Marvel Cinematic Universe (MCU). Most of the time, they’re seen assuming the appearances and identities of other humans on Earth.
5 Awards Categories Ben Affleck's "Air" Could Be Nominated In For 2024's Oscars
The reviews are out for “Air” and it seems like critics are on cloud nine for the film with a staggering 99% on Rotten Tomatoes as of the time of writing. The film recounts the story of Matt Damon’s Sonny Vaccaro, a shoe salesman and basketball guru, and his team at Nike as they hustle, negotiate, scream and work their way into closing a deal with the greatest basketball athlete of all time.
Is "The Authority" Gonna Be James Gunn's New Justice League?
What if the Justice League ruled the world? A concept that’s been thoroughly explored in the world of DC’s alternate universes. Those who have grown up watching Bruce Timm’s phenomenal animated series “Justice League” and “Justice League Unlimited” would have remembered the Justice Lords. A ruthless version of the team that seized control of the world’s governments to play protector and ruler.
"Shazam! Fury Of The Gods": Review & Post-Credits Scene Explained
Unless you’ve been living under a rock, you probably know that Warner Bros Discovery’s DC Universe (DCU) is about to see some major shake-ups. Heck, they even dropped the “E” in the DCEU! With James Gunn and Peter Safran at the wheel, fans can look forward to a brand new vision of beloved heroes with new films and TV shows set in a universe after the events of “The Flash”.
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