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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

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By Shu-Ting Hung, Gabriel R. Linares, Wen-Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Sarah Beth Perry, Jonathan Chang, Alexander Couto, Jesse D. Lai, Yichen Li, Eric A. Hendricks, Berislav V. Zlokovic, Dion Dickman, J. Parker, Daniela C. Zarnescu, Fen-Biao Gao, Justin Ichida, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Duhaime, Claudia Maios, Joscany Perez, Samuel V. Alworth
| Cell Press Verified
Main text (Cell 186, 786–802.e1–e15; February 16, 2023) In our original published article, we performed western blots and imaging of induced motor neurons (iMNs) to elucidate the mechanism through which PIKFYVE inhibition causes secretion and clearance of aggregation-prone proteins such as phosphorylated TDP-43 (pTDP-43). Since publication, we have become aware of 3 errors in figure legends or images that we are now correcting.
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