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Yingxiao Shi

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Articles

Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy

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By Shi Yue, Zheng Guo, Crystal Pan, Xueyuan A. Jing, Litao Tao, Tai Nguyen, Jiaqi Tang, Yanpui Chan, Humberto Contreras-Trujillo, Du Jiang, Xue Yan, Hang Xiang, Xugeng Liu, Celia Bloom, Asiri Ediriwickrema, Sebastian E. Koschade, Xiao Wang, Ziyuan Wang, Yingxiao Shi, Daniel B. McKim, Rong Lu, Ravindra Majeti, Chao Zhang, Qi-Long Ying, Natalie Shu
| Cell Press Verified
Results Overcoming key bottlenecks in engineered myeloid cell therapy requires a scalable source of myeloid progenitors. We developed a chemically defined culture formulation, termed SCF/2i, composed of stem cell factor (SCF), GDC-0879 (BRAF inhibitor),18 and SKL2001 (a reported Wnt/β-catenin modulator),19 that enabled log-phase expansion of primary mouse bone marrow cells for more than 50 days (Figure 1A; see STAR Methods).
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Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy

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By Shi Yue, Zheng Guo, Crystal Pan, Xueyuan A. Jing, Litao Tao, Tai Nguyen, Jiaqi Tang, Yanpui Chan, Humberto Contreras-Trujillo, Du Jiang, Xue Yan, Hang Xiang, Xugeng Liu, Celia Bloom, Asiri Ediriwickrema, Sebastian E. Koschade, Xiao Wang, Ziyuan Wang, Natalie Shu, Yingxiao Shi, Daniel B. McKim, Rong Lu, Ravindra Majeti, Chao Zhang, Qi-Long Ying
| Cell Press Verified
Results Overcoming key bottlenecks in engineered myeloid cell therapy requires a scalable source of myeloid progenitors. We developed a chemically defined culture formulation, termed SCF/2i, composed of stem cell factor (SCF), GDC-0879 (BRAF inhibitor),18 and SKL2001 (a reported Wnt/β-catenin modulator),19 that enabled log-phase expansion of primary mouse bone marrow cells for more than 50 days (Figure 1A; see STAR Methods).
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C9orf72 hexanucleotide repeat RNA drives transcriptional dysregulation through genome-wide DNA:RNA hybrid G-quadruplexes

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By Honghe Liu, Mingming Liu, Yang Liu, Gege Gui, Tapas Paul, Yu-Ning Lu, Zhiyuan Huang, Haocheng Wang, Yatao Xiao, Goran Periz, Yingxiao Shi, Justin Ichida, Sua Myong, Hongkai Ji, Jiou Wang, Zhongfan Zheng
| Cell Press Verified
Keywords amyotrophic lateral sclerosis C9ORF72 repeat RNA G-quadruplex DNA-RNA interaction Get full text access Log in, subscribe or purchase for full access. References 1. Hannan, A.J. Tandem Repeat Polymorphisms Tandem Repeat Polymorphisms: Genetic Plasticity, Neural Diversity and Disease Springer, 2012; 1-9 2. Ranum, L.P.W. ∙ Cooper, T.A. RNA-mediated neuromuscular disorders Annu. Rev. Neurosci. 2006; 29:259-277 3. DeJesus-Hernandez, M. ∙ Mackenzie, I.R. ∙ Boeve, B.F. ...
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