Sarel J. Fleishman

Keywords immunotherapy hFcγRIIB agonism antagonism crystal structure epitope affinity receptor triggering antibody Introduction Fc gamma receptors (FcγR) are expressed by multiple cell types and serve to regulate the functions of immunoglobulin G (IgG) antibodies within the body, thereby mediating various aspects of humoral immunity in health and disease.1 A number of genetic polymorphisms and/or copy-number variations in both mouse and human FcγR predispose to, or ameliorate, autoimmune...

Editor’s summary Signaling by the cytokine TNF mediates immune responses to infections, and its dysregulation underlies numerous inflammatory disorders. Binding of trimeric TNF to its receptor TNFR1 stimulates signaling by trimeric and higher-order TNFR1. Noting that the transmembrane domains (TMDs) of other TNFR superfamily members support ligand-dependent receptor activation, Wang et al.

Abstract Psychedelic indolethylamines with therapeutic potential are naturally produced in plants, fungi, and animals. Here, we elucidated the complete N,N-dimethyltryptamine (DMT) biosynthetic pathway in hallucinogenic plant species traditionally used in shamanic rituals for spiritual healing.