Sarwish Rafiq

Abstract Combination radiotherapy (RT) and αPD-L1 therapy has potential to enhance local and distant (abscopal) tumor control, however, clinical results in humans have been variable. Using murine melanoma models, we found RT + αPD-L1 increases intra-tumor progenitor CD8+ PD-1+ TCF-1+ T cells. This increase depends on trafficking of the PD-1+ TCF-1+ cells from the tumor-draining lymph node (TdLN) to the tumor.

Abstract Diet-derived nutrients are inextricably linked to human physiology by providing energy and biosynthetic building blocks and by functioning as regulatory molecules. However, the mechanisms by which circulating nutrients in the human body influence specific physiological processes remain largely unknown.

CAR-T cell immunotherapy treatment has transformed the treatment of some cancers in some patients. But which patient factors determine the success of CAR-T therapies, and how universal is the applicability of CAR-T and its variations such as CAR-NK? In this webinar, an expert panel will discuss how feasible it is to predict the potential of therapies based on patients’ immunological states, and explore what can be done to adjust CAR-T or other immunotherapies to accommodate those patients.