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ArticleOnline now102324Open access 1Department of Medicine, The University of Chicago, Chicago, IL 60637, USA 2Department of Obstetrics & Gynecology, The University of Chicago, Chicago, IL 60637, USA 3Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA 4Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA 5Health Science, DePaul University, Chicago, IL 60614, USA 6Department of Radiology and Imaging Sciences, Emory University...
Abstract Diet-derived nutrients are inextricably linked to human physiology by providing energy and biosynthetic building blocks and by functioning as regulatory molecules. However, the mechanisms by which circulating nutrients in the human body influence specific physiological processes remain largely unknown.
Anadon et al. demonstrate that human ovarian cancer-infiltrating T cells exhibiting hallmarks of sustained and active tumor antigen recognition are restricted to ∼13% of CD8+ T cells at tumor beds, corresponding to ∼3% of CD8+ clonotypes. These clonotypes represent TRM lymphocytes with a reservoir that retains features of stemness.
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