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Sayanur Rahaman on Muck Rack

Sayanur Rahaman

As seen in: Science Magazine, Cell Reports
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Articles

Protocol for Quantifying Silent Ribosome Induction Using Polysome Profiling

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By Sayanur Rahaman, Samuel Mondal, Nicole Schiffelholz, Attila Becskei
| preprints.org
Submitted: 04 December 2025 You are already at the latest version Translationally silent ribosomes have become an important focus in RNA biology. Lacking mRNAs, they represent a hibernating ribosome state. Their quantification remains challenging.
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Heat shock induces silent ribosomes and reorganizes mRNA turnover

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By Sayanur Rahaman, Nitish Mittal, Klemens Fröhlich, Mihaela Zavolan, Attila Becskei, Nicole Schiffelholz
| Cell Reports Verified
Keywords mRNA metabolic labelling Saccharomyces cerevisiae macrophage proteomics mRNA half-life polysome profiling xrn1 codon optimality stress granule 4-thiouracil Research topic(s) CP: Molecular biology CP: Genomics Introduction To initiate translation, mRNA molecules associate with the small subunit of the ribosome in the cytoplasm, after which the full ribosome is assembled.1,2 Following multiple rounds of translation, most mRNA molecules are degraded co-translationally, completing the...
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Polysome propensity and tunable thresholds in coding sequence length enable differential mRNA stability

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By Samantha Hoffman, Bernard Cazelles, Wei Jiang, Sayanur Rahaman
| Science Magazine Verified
Research Article SYSTEMS BIOLOGY INTRODUCTION The expression of a gene can be tuned by a single factor controlling more than one of the processes involved in mRNA and protein turnover. For example, many of the highly expressed genes have a marked codon bias, and optimal codons are typically decoded by abundant tRNAs (1).
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